background: cirrhotic patients are at a greater risk of different kinds of arrhythmias. despite the well-known arrhythmogenic effects of halothane, developing countries continue to use halothane due to its low cost. this study was designed to investigate the pathophysiology of halothane untoward effects on heart rhythm moreover was aimed to explore the effect of halothane anesthesia on the thre...

Barbiturate Protection From Cerebral Infarction in Primates • Baboons were anesthetized with halothane or pentobarbital prior to middle cerebral artery (MCA) occlusion to test the protective effect of barbiturates against stroke in primates. Significantly less infarction was found in animals that received 90 mg per kilogram pentobarbital or more than occurred in control animals. Because of card...

Behavioral effects of methyl angolensate were investigated in mice and rats. Spontaneous motor activity, pentobarbital sleeping time, amphetamine-stereotyped behaviour, exploratory activity and apomorphine-induced climbing studies in mice were evaluated. The results revealed that methyl angolensate reduced spontaneous motor activity in mice, prolonged the duration of pentobarbital sleeping time...

A procedure for long lasting general anaesthesia in gulls (LaTus sp.) is described. It is based on an initial basal intramuscular dose of pentobarbital sodium, supplemented if necessary by intravenous injection to effect of the same agent. Additional intramuscular pentobarbital is used to extend the duration of anaesthesia. The labile respiration of the birds is supported with oxygen. In cases ...

We describe a liquid-chromatographic method involving a new, nonsilica column (XAD-2, Hamilton Co.) for pentobarbital in plasma. Plasma is extracted with chloroform after addition of the internal standard, 5-ethyl-5-p-tolyl-barbituric acid. Acidic drugs are back-extracted into alkali, then chromatographed on the resin-base reversed-phase column. The use of alkaline mobile phase allows enhanced ...