Pentavalent antimonials, including meglumine antimoniate and sodium stibogluconate, have been used for more than half a century in the therapy of the parasitic disease leishmaniasis. Even though antimonials are still the first-line drugs, they exhibit several limitations, including severe side effects, the need for daily parenteral administration and drug resistance. The molecular structure of ...

The World Health Organization has classified the leishmaniasis as a major tropical disease. An effective vaccine against leishmaniasis is not available and chemotherapy is the only effective way to treat all forms of disease. However, current therapy is toxic, expensive and the resistance has emerged as a serious problem, which has compelled the search for new antileishmanial agents. The aim of...

Diagnosis and therapy of cutaneous leishmaniasis (CL) can be difficult due to the variability of the clinical pictures and resistance to therapy. There is no vaccine currently available for CL. The aim of the present review is to describe different topical treatment modalities for old world CL. The mainstays of treatment for old world CL are penta...

purpose: to introduce the importance and world prevalence of ocular leishmaniasis (ol), its clinical manifestations, and diagnostic and management features with more emphasis on iranian cases. methods: we reviewed all available articles published about ol during recent 50 years. results: ol is an ocular protozoal infection which is widespread in the world but is more common in developing countr...

A graph is said to be symmetric if its automorphism group is transitive on its arcs. A complete classification is given of pentavalent symmetric graphs of order 24p for each prime p. It is shown that a connected pentavalent symmetric graph of order 24p exists if and only if p=2, 3, 5, 11 or 17, and up to isomorphism, there are only eleven such graphs.