Neisseria meningitidis is one of the important cause of meningitis and has been extremely susceptible to penicillin. Nevertheless, moderately penicillin resistant strains have been reported in some parts of the world. To our knowledge, there is no such report in Malaysia. We report two clinical isolates that were found to have MICs of decreased susceptibility to penicillin by the agar dilution ...

Minimal inhibitory concentration (MIC) values for penicillin G, tetracycline, amoxicillin, and actinomycin D were determined for 81 strains of Neisseria gonorrhoeae isolated from patients attending public health clinics in the Piedmont region of South Carolina. Gonococcal isolates were also screened for highlevel resistance to streptomycin. Significant positive correlations (r >/= 0.45, P </= 0...

conclusions: considering the low rate of ceftriaxone resistance amongst isolated pneumcocci.in this study, only ceftriaxone treatment of adult patients with invasive pneumococcal infections (other than cns infections) is sufficient; but pediatric patients and patients with cns infections should be treated with ceftriaxone and vancomycin. apparently, diminution of vancomycin use can be resulted ...

Macrolide resistant Streptococcus pneumoniae has been increasing rapidly in Southeast Asia. A review from 2000 through 2011 at Charoenkrung Pracharak Hospital that evaluated drug resistance to erythromycin found S. pneumoniae from 158 of the 390 (40.5%) patients: 3.6% intermediate, 36.9% highly resistant. A significant correlation was found between macrolide resistant S. pneumoniae and penicill...

BACKGROUND S. pneumoniae is the leading cause of morbidity and mortality worldwide. P-lactam antibiotics were very effective against S. pneumoniae, however resistance to this class of antibiotic has become an increasing problem. OBJECTIVES To assess the clinical differences between penicillin-sensitive and penicillin-resistant pneumococcal pneumonia. METHODS The medical records of 306 patie...

MICs of 21 beta-lactams were determined by agar dilution against 283 penicillin-susceptible (pen-S), 122 intermediate (pen-I) and 23 fully penicillin-resistant (pen-R) pneumococci. MICs of all beta-lactams increased with increasing MICs of penicillin. Clometocillin was the most active penicillin against pen-I or pen-R pneumococci. All oral cephalosporins except cefuroxime and cefpodoxime were l...

BACKGROUND The prevalence of multiantimicrobial resistance among Streptococcus pneumoniae continues to increase worldwide. In patients presenting with infection possibly due to pneumococci, recognition of risk factors that would identify those likely to have an antibiotic-resistant isolate might assist clinicians in choosing the most appropriate empirical therapy. METHODS A prospective cohort...

SM-295291 and SM-369926 are new parenteral 2-aryl carbapenems with strong activity against major causative pathogens of community-acquired infections such as methicillin-susceptible Staphylococcus aureus, Streptococcus pneumoniae (including penicillin-resistant strains), Streptococcus pyogenes, Enterococcus faecalis, Klebsiella pneumoniae, Moraxella catarrhalis, Haemophilus influenzae (includin...