Introduction: Pemphigus is a relatively rare autoimmune bullous disease involving skin and mucous epithelia. The disease occurs as a result of production of auto-antibodies against inter-cellular epithelia especially cadherin and desmoglein. Interleukin 17 (IL-17) is one of the specific cytokines of T helper. IL-17 plays an important role in delayed type reaction and recruits neutrophils and mo...

Pemphigus is a group of rare and potentially fatal autoimmune blistering diseases that are associated with auto-antibodies that target intercellular adhesion molecules. Incidence of pemphigus varies among populations, with the lowest incidence in Switzerland and Finland at 0.6-0.76 per million per year and the highest in Jewish communities at 16.1-32 per million per year. Pemphigus is associate...

Binding of anti-cell surface pemphigus autoantibodies to cultured human epidermal cells stimulates synthesis and secretion of plasminogen activator (PA). Increases in PA activity were detected within 6 h of the addition of IgG and stimulation was dependent upon IgG concentration. Stimulation of PA activity was inhibited by cycloheximide, which indicates that synthesis of protein was necessary. ...

INTRODUCTION Pemphigus comprises a group of autoimmune blistering diseases that affect the skin and mucous membranes. Its clinical and epidemiologic features vary according to geographic location and ethnic background. OBJECTIVE An exhaustive search of the literature reveals very few reports of the epidemiology of pemphigus in setting. Our aim, thus, was to conduct a retrospective study of th...

Pemphigus vulgaris (PV) is an autoimmune disease characterized by blistering and erosions on skin and mucous membranes due to acantholysis. It is caused by autoantibodies against desmosomal caderins desmoglein 3 (Dsg 3) which are calcium dependent cell adhesion molecules. The measurement of Dsg 3-ELISA had been shown to be a sensitive and specific test for the diagnosis of PV in addition to the...

Since the mid-1970s, membrane modules became available and plasma separation techniques have gained importance. Therapeutic apheresis (TA) has been successfully introduced in a variety of autoantibody-mediated diseases. In dermatology, TA is increasingly applied as a support treatment for severe and/or refractory autoimmune bullous diseases. All autoimmune disease are characterized by autoantib...

BACKGROUND Trichoscopy is becoming increasingly popular in diagnosing hair and scalp diseases. Scalp involvement in pemphigus is common. The scalp may be the first or only site of clinical manifestation of the disease. OBJECTIVE The aim of this study was to analyze whether trichoscopy may be useful in aiding differential diagnosis of scalp lesions in patients with pemphigus vulgaris and pemph...

Paraneoplastic pemphigus (PNP) is a rare multisystem, autoimmune disease with prominent mucocutaneous manifestations, occurring most commonly in association with haematological malignancies. It is characterised by the presence of circulating autoantibodies against epithelial adhesion proteins. We report a 46-year-old woman with common variable immunodeficiency who developed paraneoplastic pemph...

Background Pemphigus is a severe bullous autoimmune skin disease. foliaceus (PF) characterized by antidesmoglein (Dsg) 1 IgG causing epidermal blistering; mucosal pemphigus vulgaris (mPV) anti-Dsg3 inducing erosions in the mucosa; and mucocutaneous (PV) affecting both, with autoantibodies targeting Dsg1 Dsg3. Objectives To characterize Ca2+ flux pathway delineate its importance pathogenesis cli...

d-penicillamine is one of the disease-modifying anti-rheumatic drugs (dmards). drug-induced pemphigus is not frequently associated with d-penicillamine, and to date, the number of reported cases is about a hundred. most reports of d-penicillamine-induced pemphigus vulgaris are in patients with rheumatoid arthritis. it has rarely been reported in patients not taking d-penicillamine. we report a ...