نتایج جستجو برای: peg concentration
تعداد نتایج: 395749 فیلتر نتایج به سال:
Abstract The fabrication of 2,6‐bis(1,2,3‐triazol‐4yl)pyridine (btp) based metallo‐supramolecular gels has been mainly focusing on organogels. Only recently, the synthesis and hydrogel formation linear poly(ethylene glycol) (PEG) with multiple btp units in main chain are reported. In this manuscript, hydrogels that constructed using tetra‐arm star PEG‐modified end‐groups upon complexation trans...
due to unique applications of palladium nanoparticles, synthesis of these nanoparticles by a simple andlow cost method is very important. in this work, pd nanoparticles were synthesized with narrow sizedistribution by loading metal salt (pd(oac)2 ) into the polymeric matrix (peg) as reducing agent andstabilizer. also, the effect of metal salt concentration and peg molecular weight on the conver...
This article focuses on the use of polyethylene glycol (PEG) as a virioplankton concentrating agent to characterize the diversity of natural communities of aquatic viruses. PEG is well known as good inductor of attractive interactions that crystallize viruses in the interpolymer spaces between PEG molecules. Added to a co-precipitant it allows an easy and rapid concentration of virioplankton. A...
Polyethylene glycol (PEG) is often used in protein crystallography as a low-ionic-strength precipitant for crystallization and as a cryoprotectant for low-temperature data collection. Prompted by the discovery of an apparent L-lactate molecule bound in the active site of the Escherichia coli PutA proline dehydrogenase domain crystal structure, the L-lactate concentration of several PEG solution...
The pharmacokinetics, excretion, and tissue distribution of [(14)C]-labeled polyethylene glycol-alanine (PEG-Ala) were determined after slow bolus administration into the femoral vein of male CD-1 mice. The pharmacokinetics of PEG-Ala in blood and plasma revealed a biphasic elimination with a terminal half-life of 20 h. Eighty-five percent of the excreted material was voided in the urine and th...
S-Nitrosothiols are an interesting class of nitric oxide (NO) donors used for the treatment of circulation disorders. In this study, we developed a novel macromolecular NO donor in which 10 NO molecules were covalently bound to polyethylene glycol (PEG)-conjugated bovine serum albumin (BSA) through S-nitrosothiol linkages (PEG-poly SNO-BSA). Intermolecular disulfide linkages possibly formed dur...
Thiazolyl cyclic peptide antibiotics are known for their poor aqueous solubility and unfavorable pharmacokinetics (PK) and hence pose challenging tasks in developing these antibiotics as clinical candidates. In the current paper, we report a possible way to address these challenges with exemplification of our antibiotic PM181104. The approach was to prepare formulations with known excipients, P...
In recent years, magnetic resonance imaging (MRI) with diffusion-weighted imaging (DWI) has seen wide clinical use, such as for early detection of cerebrovascular diseases and whole body screening for tumors. The apparent diffusion coefficient (ADC) standard phantom, which mimics the ADC values of several lesions in the body, is indispensable for the development of new pulse sequences for DWI, ...
The present work investigates the feasibility of the design of an enteric coated microporous osmotic pump tablet (ECMOPT) to prolong the drug release of an antipsychotic drug, quetiapine fumarate (QTF). The ECMOPT consisted of an osmotic core coated with a microporous membrane (MPM) made up of cellulose acetate and PEG 4000 as in situ micropore former. The effect of formulation variables such a...
Human interferon (IFN) has well established beneficial effects in treating relapsing forms of multiple sclerosis, but current first-line treatment requires frequent (from daily to weekly) parenteral administration. A 20-kDa polyethylene glycol (PEG)conjugated IFN -1a (PEG-IFN -1a) is being developed to decrease the frequency of administration and improve patient convenience and compliance. We p...
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