In the preformulation study physical compatibility of the drug-excipient was screened and compatibility was observed between Zaltoprofen and selected solubilizers. In the drug solubilizers interference study no interference was observed in UV spectrophometric analysis of Zaltoprofen in presence of employed solubilizers. Aqueous solubility of Zaltoprofen was found 0.028 mg/ml. The solubilizers s...

BACKGROUND Adequate bowel preparation is an essential prerequisite for complete mucosal visualization during colonoscopy. Polyethylene glycol (PEG) solutions are commonly used. However the large volume of the solution is often poorly tolerated. Addition of Lubiprostone (LB) could improve the adequacy of standard PEG preparation & reduce requirement. The aims to assess adequacy of PEG preparatio...

Cengkeh (Syzygium aromaticum L) merupakan salah satu tanaman herbal yang sering digunakan masyarakat karena kandungan utama minyak atsiri bunga cengkeh (Syzigium aromaticum) adalah eugenol memiliki khasiat sebagai antiinflamasi. Formulasi salep telah dilakukan dengan membuat sediaan dalam basis larut air (PEG). Salah persyaratan stabil. Penggunaannya secara tradisional memerlukan waktu penyiapa...

BACKGROUND Quality of bowel preparation prior to colonoscopy is essential. Studies have shown a reduced volume of polyethylene glycol (PEG) with bisacodyl may improve visualization and tolerability, but results have varied. Therefore, a meta-analysis was performed to analyze the efficacy of a low-volume PEG bowel preparation with bisacodyl for bowel preparation prior to colonoscopy. METHODS M...

PURPOSE The purpose of this study was to demonstrate the valence of cyclic RGD peptides, P-RGD (PEG(4)-c(RGDfK): PEG(4) = 15-amino-4,710,13-tetraoxapentadecanoic acid), P-RGD(2) (PEG(4)-E[c(RGDfK)](2), 2P-RGD(4) (E{PEG(4)-E[c(RGDfK)](2)}(2), 2P4G-RGD(4) (E{PEG(4)-E[G(3)-c(RGDfK)](2)}(2): G(3) = Gly-Gly-Gly) and 6P-RGD(4) (E{PEG(4)-E[PEG(4)-c(RGDfK)](2)}(2)) in binding to integrin α(v)β(3), and ...

The poly(ethylene) glycol (PEG) capped mancozeb nanoformulation was prepared by the ultrasonic method using a 1% solution and 20% capping agent, PEG-4000. synthesized characterized UV-visible, FTIR, SEM TEM techniques. photolytic photo catalytic experiments were carried out in Borosil glass bottle presence of sunlight, varying pH proportions at single fortification level (1.0 g/mL) ground water...

conclusions according to achieved results, it was defined that swcnts is a quite effective adsorbent in removal of 2, 4-d from aqueous environments. results maximum adsorption capacity of the swcnts was 979.6 mg/g at ph5, contact time 45 min, initial concentration of 5000 µg/l, and 23 ± 2 ◦c temperatures, when 97.96% of 2, 4-d herbicide were removed. the adsorption equilibriums were analyzed by...

BACKGROUND Response of parathyroid hormone (PTH) to vitamin D supplementation is determined by the baseline PTH level and change in vitamin D status. Conflicting reports in Blacks exist on the PTH response to vitamin D to supplementation. METHODS During 3 winters from 2007-2010, 328 healthy Blacks (median age, 51 years) living in Boston, MA were randomized into a 4-arm, double-blind trial for...

Paclitaxel (PTX) is one of the most effective antineoplastic drugs. Its current clinical administration Taxol(®) is formulated in Cremophor EL, which causes serious side effects. Nanoparticles (NP) with lower systemic toxicity and enhanced therapeutic efficiency may be an alternative formulation of the Cremophor EL-based vehicle for PTX delivery. In this study, novel amphipathic 4-arm-PEG-TPGS ...