Thermotoga maritima TruB, an enzyme responsible for the formation of pseudouridine in tRNA, has been purified and crystallized by the hanging-drop vapour-diffusion method in 100 mM citrate pH 3.5, 200 mM Li(2)SO(4), 20% glycerol, 13% PEG 8000. Crystals display orthorhombic symmetry, with unit-cell parameters a = 47.39, b = 83.88, c = 98.72 A, and diffract to 2.0 A resolution using synchrotron r...

AIM To evaluate the complications associated with pegging of porous hydroxyapatite orbital implants. METHODS Complications associated with pegging were retrospectively reviewed from the charts of 100 of 133 patients with hydroxyapatite implantation from 1993 to 2000. RESULTS 48 (48%) of the 100 hydroxyapatite implanted patients who had undergone pegging were found to have problems with thei...

avoid from catch by the reticuloendothelial system (RES). It has been clarified that the prolongation of liposome circulation in the blood and passive targeting to the tumor was achieved by PEG modification of the liposomal surface. In terms of their physicochemical properties by PEG modification, many studies have examined the interaction between the prolonged circulation time of liposomes and...

Carrot is one of the most frequently grown vegetables in Poland and world. Seed-borne pathogenic fungi negatively influence their quality as well quantity carrot root yield. Melatonin a PGR, which includes protective effects against biotic abiotic stress factors antioxidant effects. The aim this experiment was to determine effect osmopriming with melatonin on germination, vigor seeds health. we...

Intracellular delivery of drugs and DNA is hampered by the cytotoxicity of some carrier systems (such as cationic lipids) and degradation of drugs or DNA as a results of endocytic processing. It has been shown that the coupling of HIV-1 TAT protein, or shorter TAT peptides derived from this protein, to other proteins and small colloidal particles facilitates their efficient intracellular delive...

BACKGROUND PEG-based laxatives are considered today the gold standard for the treatment of constipation in children. PEG formulations differ in terms of composition of inactive ingredients which may have an impact on acceptance, compliance and adherence to treatment. We therefore compared the efficacy, tolerability, acceptance and compliance of a new PEG-only formulation compared to a reference...

Alkynyl selenides were synthesized by a straightforward one-pot and three-step methodology, without the need of diselenides as starting reagents, under an oxygen atmosphere and using PEG 200 as the solvent. This procedure involves the in situ generation of dialkyl diselenides through a K3PO4-assisted reaction of an alkyl selenocyanate obtained by a nucleophilic substitution reaction between KSe...

aim : the objective of this study was to estimate the average cost of diagnosis and treatment of hepatitis c among patients based on their treatment regime, during the one course of treatment and six-month after stopping that. background : hepatitis c virus (hcv) infection is a major cause of liver-related morbidity and mortality worldwide and a major public health problem. patients and methods...