Average daily gain between birth and 30 d of age of 42,644 lambs of Swiss Black-Brown Mountain Sheep were used in this analysis. The influence of amount of pedigree information on computing time and on REML estimates of population parameters was investigated on a subset of 7,848 lambs. If all available pedigree information was used, 89.4% of the lambs had at least four complete generations of k...

Multilocus calculations, using all available information on all pedigree members, are important for linkage analysis. Exact calculation methods in linkage analysis are limited in either the number of loci or the number of pedigree members they can handle. In this article, we propose a Monte Carlo method for linkage analysis based on sequential imputation. Unlike exact methods, sequential imputa...

The open-pollinated (OP) family testing combines the simplest known progeny evaluation and quantitative genetics analyses as candidates' offspring are assumed to represent independent half-sib families. The accuracy of genetic parameter estimates is often questioned as the assumption of "half-sibling" in OP families may often be violated. We compared the pedigree- vs. marker-based genetic model...

Probability functions such as likelihoods and genotype probabilities play an important role in the analysis of genetic data. When genotype data are incomplete Markov chain Monte Carlo (MCMC) methods, such as the Gibbs sampler, can be used to sample genotypes at the marker and trait loci. The Markov chain that corresponds to the scalar Gibbs sampler may not work due to slow mixing. Further, the ...

OBJECTIVE Intramuscular fat is one of the meat quality traits that is considered in the selection strategies for Hanwoo (Korean cattle). Different methods are used to estimate the breeding value of selection candidates. In the present work we focused on accuracy of different genotype relationship matrices as described by forni and pedigree based relationship matrix. METHODS The data set inclu...

The first national single-step, full-information (phenotype, pedigree, and marker genotype) genetic evaluation was developed for final score of US Holsteins. Data included final scores recorded from 1955 to 2009 for 6,232,548 Holsteins cows. BovineSNP50 (Illumina, San Diego, CA) genotypes from the Cooperative Dairy DNA Repository (Beltsville, MD) were available for 6,508 bulls. Three analyses u...

The philosophy of time travel has an illustrious pedigree, having seen ground-breaking physical and philosophical treatments in the late 1940s early 1950s from Kurt Gödel [...]

Large population biobanks of unrelated individuals have been highly successful in detecting common genetic variants affecting diseases of public health concern. However, they lack the statistical power to detect more modest gene-gene and gene-environment interaction effects or the effects of rare variants for which related individuals are ideally required. In reality, most large population stud...

The purpose of the article is to illustrate the use of pedigree analysis to evaluate mtDNA diversity in a selected population of pedigree dogs, to describe the paths of mtDNA inheritance and to estimate the spread of potential pedigree errors or mutations that occurred in different generations of ancestors. Hovawart, old German breed, was used as an example. The number and frequencies of mtDNA ...

OBJECTIVE To develop a population-based proband-oriented pedigree information system that can be easily applied to various diseases in genetic epidemiological studies, making allowance for the capture of theoretical family relationships. DESIGNS AND MEASUREMENTS: A population-based proband-oriented pedigree information system with ties of consanguinity based on both population-based household r...