A novel nonlinear PDE based image denoising and restoration approach is provided in this article. The proposed anisotropic diffusion based technique is derived from the influential Perona-Malik nonlinear diffusion scheme, representing an enhanced version of that scheme. Our model is based on new versions of the edge-stopping function and the conductance parameter. The proposed PDE-based filteri...

BACKGROUND Mast cell and basophiles are thought to be central to inflammation that has an allergic basis as allergens activate these cells in an IgE-dependent manner to generate mediators such as histamine, eicosanoids and cytokines. Phosphodiesterase (PDE) is known to exist as multiple molecular forms of enzyme that metabolise the second messengers. Studies of our own have shown that, of a var...

PURPOSE The identification of the phosphodiester (PDE) (31)P MR signals in the healthy human breast at ultra-high field. METHODS In vivo (31)P MRS measurements at 7 T of the PDE signals in the breast were performed investigating the chemical shifts, the transverse- and the longitudinal relaxation times. Chemical shifts and transverse relaxation times were compared with non-ambiguous PDE signa...

The second messenger cyclic nucleotides, cyclic AMP and cyclic GMP, mediate relaxation of airways smooth muscle and suppression of multiple inflammatory cell functions. The intracellular concentrations of these cyclic nucleotides are regulated by a superfamily of phosphodiesterase (PDE) enzymes which break down cAMP and cGMP and, thereby, affect airway tone and inflammation. Theophylline and ot...

A new fast likelihood computation approach is proposed for HMM-based continuous speech recognition. This approach is an extension of the partial distance elimination (PDE) technique. Like PDE, the extended PDE (EPDE) approach aims at finding the most prominent Gaussian in a GMM for a given observation, and approximating the GMM’s likelihood with the identified Gaussian. EPDE relies on a novel s...

5'-Phosphodiesterase (5'-PDE) catalyzes the hydrolysis of ribonucleic acid to obtain a mixture of ribonucleotides, such as 5'-guanosine monophosphate and 5'-adenosine monophosphate. In this study, a 5'-PDE was newly isolated and purified from Aspergillus fumigatus. Following purification, this enzyme exhibited a specific activity of 1036.76 U/mg protein, a molecular weight of 9.5 kDa, and an op...

This paper addresses the output feedback stabilization of an ODE–PDE cascade. The PDE takes form a 1-D reaction–diffusion equation. ODE enters into via Dirichlet/Neumann/Robin boundary condition. It is assumed that both and PDE, selected as Dirichlet trace, are available for control. proposed control strategy finite-dimensional observer-based controller. Under suitable structural controllabilit...

the aim of this investigation was to prepare, characterize and optimize the aceclofenac proniosomes using central composite design and carry out stability studies. three independent variables selected were molar ratio of drug to lipid (x1), surfactant loading (x2) and volume of hydration (x3). based on central composite design, 16 batches of proniosomes were prepared by slurry method and evalua...

Inactivation of the cyclic nucleotide signal in granulosa cells depends on a complex array of cyclic nucleotide phosphodiesterases (PDE). In order to examine the role of PDE in cyclic AMP (cAMP) signaling in granulosa cells, the present study examined the expression of PDE4D proteins and regulation of cAMP-PDE activities in cultured rat granulosa cells. The results of immunoblot analyses showed...

The present study focused on the possible protective effect of Prunus domestica extract (PDE) against radiation induced damage in liver and small intestine of Swiss albino distributed into five groups of 10 mice each. fruits extract (PDE) was evaluated for in vivo activity against whole body gamma irradiation in Radiation induced histological lesions and antioxidant parameters were observed. PD...