We report the identification and primary sequence of PCM-1, a 228-kD centrosomal protein that exhibits a distinct cell cycle-dependent association with the centrosome complex. Immunofluorescence microscopy using antibodies against recombinant PCM-1 demonstrated that PCM-1 is tightly associated with the centrosome complex through G1, S, and a portion of G2. However, late in G2, as cells prepare ...

As a promising nonvolatile memory technology, Phase Change Memory (PCM) has many advantages over traditional DRAM. Multilevel Cell PCM (MLC) has the benefit of increased memory capacity with low fabrication cost. Due to high per-cell write power and long write latency, MLC PCM requires careful power management to ensure write reliability. Unfortunately, existing power management schemes applied...

OBJECTIVES To elucidate the role of the pcm-tolCsm operon in the multidrug resistance of Stenotrophomonas maltophilia. METHODS The presence of the pcm-tolCsm operon was verified by RT-PCR. The phylogenetic relationship between the outer membrane proteins known to be involved in functional tripartite efflux in Escherichia coli, Pseudomonas aeruginosa and S. maltophilia was analysed. The contri...

In C. elegans, genome-wide screens have identified just five essential centriole-duplication factors: SPD-2, ZYG-1, SAS-5, SAS-6, and SAS-4 [1-8]. These proteins are widely believed to comprise a conserved core duplication module [3, 9-14]. In worm embryos, SPD-2 is the most upstream component of this module, and it is also essential for pericentriolar material (PCM) recruitment to the centriol...

Paracoccidioidomycosis (PCM) is a systemic granulomatous disease caused by the dimorphic fungus Paracoccidioides brasiliensis. Anti-PCM vaccine formulations based on the secreted fungal cell wall protein (gp43) or the derived P10 sequence containing a CD4(+) T-cell-specific epitope have shown promising results. In the present study, we evaluated new anti-PCM vaccine formulations based on the in...

We describe a new architecture for passive robots and haptic displays, which we call a programmable constraint machine (PCM). An n-dof PCM can, under computer control, exhibit constraints (smooth, impenetrable virtual surfaces of dimensionality < n), or it can allow free n-dof motion. At the heart of the PCM is a nonholonomic element, which is used as a continuously variable transmission (CVT)....

The demands of larger memory capacity in high-performance computing systems have motivated the researchers to explore alternatives of DRAM (dynamic random access memory). Since PCM (phase change memory) provides high-density, good scalability and non-volatile data storage, it has received significant amount of attention in recent years. A crucial bottleneck in wide-spread adoption of PCM, howev...

Energy piles-A fairly new renewable energy concept-Use a ground heat exchanger (GHE) in the foundation piles to supply heating and cooling loads to the supported building. Applying phase change materials (PCMs) to piles can help in maintaining a stable temperature within the piles and can then influence the axial load acting on the piles. In this study, two kinds of carbon-based composite PCMs ...

This study investigated the role of antioxidant enzyme system following crude hydroethanolic extract of Moringa oleifera leaves (MO) in acute paracetamol (PCM) induced hepatotoxicity. Hydroethanolic extract (80%) of MO (200 mg/kg and 800 mg/kg; p.o) was pre-administered before a single oral dose of 3 g/kg PCM intoxication to male Sprague-Dawley rats. Pre-treatment of the extract was found to ha...

In this paper, we examine the performance of fuzzy clustering algorithms as the major technique in pattern recognition. Both possibilistic and probabilistic approaches are explored. While the Possibilistic C-Means (PCM) has been shown to be advantageous over Fuzzy C-Means (FCM) in noisy environments, it has been reported that the PCM has an undesirable tendency to produce coincident clusters. R...