OBJECTIVES Pyrrolo[2,1-c][1,4]benzodiazepine (PBD) dimers are synthetic sequence-selective interstrand DNA minor-groove cross-linking agents developed from anthramycins. We investigated the antibacterial activity of three dimers, SJG-136, DRG-16 and ELB-21, which differ in the structure of the PBD monomeric unit and the length of the linker region between the two identical PBD monomers. METHO...

Backgrounds To compare the complication rates and overall costs of self-expandable metal stents (SEMS) plastic (PS) in clinically indicated preoperative biliary drainage (PBD) prior to a pancreatoduodenectomy (PD). Methods We conducted an Australian multicentre retrospective cohort study using databases four tertiary hospitals. Adult patients who underwent endoscopic PBD PD from 2010 2019 were ...

An undoped organic small-molecule 2-(4-tert-butylphenyl)-5-(4-biphenylyl)-1,3,4-oxadiazole (PBD) and a kind of nanocomposite blending poly(methyl methacrylate) (PMMA) into PBD are employed to implement bistable resistive switching. For the bistable resistive switching indium tin oxide (ITO)/PBD/Al, its ON/OFF current ratio can touch 6. What is more, the ON/OFF current ratio, approaching to 10(4...

Peroxisomal disorders are a large group of genetically determined metabolic diseases in which the biogenesis of peroxisomes is defective or there is a deficiency of only a single enzyme activity or substrate transporter. The objective of this report is to present ten years of experience in the diagnostics of peroxisomal disorders in Poland. Very-long-chain fatty acid (VLCFA) levels as a biomark...

Polymersomes are being widely explored as synthetic analogs of lipid vesicles based on their enhanced stability and potential uses in a wide variety of applications in (e.g., drug delivery, cell analogs, etc.). Controlled formation of giant polymersomes for use in membrane studies and cell mimetic systems, however, is currently limited by low-yield production methodologies. Here, we describe fo...

Pediatric bipolar disorder (PBD) has emerged as a research field in which psychosocial treatments have provided a plethora of empirical findings over the last decade. We addressed this issue through a systematic review aimed of establishing their effectiveness and feasibility as adjunctive therapies for youth with PBD or at high-risk for PBD. A comprehensive search of databases was performed be...

Program Berbasis Data (PBD) adalah terobosan baru yang dilakukan pemerintah. Mengacu pada rapor pendidikan tentunya PBD menjadi alat sangat membantu satuan menyelesaikan beragam persoalan dihadapi. Penelitian ini berusaha untuk mendeskripsikan pemahaman pemangku kebijakan dalam melakukan analisis dasar PBD. merupakan studi kasus di dua sekolah, SMPN 3 Kualatungkal dan Satap 7 Pengabuan, sekolah...

The emergence of position-based simulation approaches has quickly developed a group new topics in the computer graphics community. These are popular due to their advantages, including computational efficiency, controllability, stability and robustness for different scenarios, whilst they also have some weaknesses. In this survey, we will introduce concept baseline position based dynamics (PBD) ...

this paper describes optimization method that combines the plackett-burman design, a factorial design and the response surface method, which were used to optimize the medium for the production of l-asparaginase by serratia marcescens sb08. four medium factors, from out of 11 medium factors, were screened by plackett-burman design experiments and subsequent optimization process to find out the o...