Although the vast majority of Alzheimer’s disease (AD) cases are of the sporadic type, mutations causing the familial form have been the focus of AD research for decades. The disease is pathologically characterised by β-amyloid (Aβ) and tau protein aggregates in neuritic plaques and neurofibrillary tangles. Furthermore, it is known that AD pathology spreads throughout the brain, most often alon...

BACKGROUND Health care planning and research would benefit from tools that enable researchers to project the future burden of Alzheimer's disease (AD) and evaluate the effect of potential interventions. METHODS We created a web-based application of the AD prevalence model developed by Brookmeyer et al (Am J Public Health 1998;88:1337-42; Alzheimers Dement 2007;3:186-91). The user defines the ...

Alzheimer’s disease (AD) is the most common form of dementia and phenotypically heterogeneous. APOE a triallelic gene which correlates with phenotypic heterogeneity in AD. In this work, we determined effect alleles on progression timeline AD using discriminative event-based model (DEBM). Since DEBM data-driven model, stratification into smaller subgroups would lead to more inaccurate models as ...

Will reading habit influence your life? Many say yes. Reading american psychiatric publishing textbook of alzheimers disease and other dementias the app textbook of geriatric psychiatry diagnostic issues in dementia is a good habit; you can develop this habit to be such interesting way. Yeah, reading habit will not only make you have any favourite activity. It will be one of guidance of your li...