Response criteria remain controversial in therapeutic evaluation for locally advanced esophageal carcinoma treated with neoadjuvant chemotherapy. We aimed to identify the predictive value of tumor regression grading (TRG) in tumor response and prognosis. Fifty-two patients who underwent neoadjuvant chemotherapy followed by esophagectomy and radical 2-field lymphadenectomy between June 2007 and ...

ID: 18746 Title: FDG-PET Histogram Distances: Novel Predictors of Tumor Response to Chemoradiotherapy Purpose: To examine the accuracy of FGD-PET histogram distances as predictors of pathologic tumor response to chemo-radiotherapy (CRT) in esophageal cancer. Methods: Twenty patients were included. A rigid registration was used to align the post-CRT PET/CT with the pre-CRT PET/CT images. The pri...

Cochlear neurodegeneration commonly accompanies hair cell loss resulting from aging, ototoxicity, or exposures to intense noise or blast overpressures. However, the precise pathophysiological mechanisms that drive this degenerative response have not been fully elucidated. Our laboratory previously demonstrated that non-transgenic rats exposed to blast overpressures exhibited marked somatic accu...

BACKGROUND NF-κB inhibits apoptosis through induction of antiapoptotic proteins and suppression of proapoptotic genes. Various chemotherapy agents induce NF-κB translocation and target gene activation. We conducted the present study to assess the predictive value of NF-κB regarding pathologic responses after receiving neoadjuvant chemotherapy. MATERIALS AND METHODS We enrolled 131 patients wi...

OBJECTIVES Pathological complete response has shown a better prognosis for patients with locally advanced rectal cancer after preoperative chemoradiotherapy. However, correlations between post-chemoradiotherapy clinical factors and pathologic complete response are not well confirmed. The aim of the current study was to identify post-chemoradiotherapy clinical factors that could serve as indicat...

To identify effects of transarterial radioembolization (TARE) with Yttrium-90 resin microspheres on histopathological analysis. All patients who underwent TARE to any liver tumor followed by a resection were included in this retrospective, IRB-approved study (n = 26). was performed using 3-day pre-calibration 90Y SPECT/CT or PET/CT. Pathologic analysis board certified pathologist 34 years exper...

Summary Neoadjuvant checkpoint inhibition in resectable non-small-cell lung cancer (NSCLC) is safe and high major pathologic response (MPR) complete (pCR) rates can be achieved combination with chemotherapy. The Checkmate 816 trial gives evidence that also leads to EFS benefit. This opens new opportunities the curative setting but raises questions: What value of adjuvant treatment inhibitors? O...

Background and Objective: P53 is a suppressive gene that plays a key role in DNA repair and apoptosis. The purpose of this study was to investigate the effect of P53 protein over-expression and some clinicopathological factors on the esophageal squamous cell carcinoma (SCC) response to neoadjuvant chemoradiotherapy. Patients and Methods: In this retrospective cohort study, 44 patients with loc...