The wheat gene Lr34 confers durable and partial field resistance against the obligate biotrophic, pathogenic rust fungi and powdery mildew in adult wheat plants. The resistant Lr34 allele evolved after wheat domestication through two gain-of-function mutations in an ATP-binding cassette transporter gene. An Lr34-like fungal disease resistance with a similar broad-spectrum specificity and durabi...

In this paper, a study on the applications of the optimization and regression techniques for optimal calculation of partial ratios of helical gearboxes with second-step double gear-sets for minimal cross section dimension is introduced. From the condition of the moment equilibrium of a mechanic system including three gear units and their regular resistance condition, models for calculation of t...

1Inserm, U693, Le Kremlin-Bicêtre, F-94276, France; 2Faculté de Médecine Paris-Sud, UMR-S693, Univ Paris-Sud 11, Le Kremlin-Bicêtre, F94276, France; 3Service de Génétique Moléculaire, Pharmacogénétique et Hormonologie, Hôpital de Bicêtre, Assistance Publique-Hôpitaux de Paris, Le Kremlin Bicêtre, F-94275, France ; 4Service de Pédiatrie et Réanimation Néonatales, Hôpital Antoine Béclère, Assista...

Androgen insensitivity syndrome is a rare disease, manifested as normal female external phenotype to infertile male with 46 XY karyotype due to different level of resistance of androgen receptor. Androgen insensitivy syndrome is classified as complete, partial and mild androgen insensitivity. Partial androgen insensitivity syndrome is further subclassified according to morphogenesis as predomin...

effect of partial natural rubber replaced with synthetic rubbers, styrene butadiene and cis butadiene, on failure and strength properties of bias tread nr/br based compound was studied by efficient and conventional sulfur curing systems and mixtures of different carbon black grades. it was observed that failure behavior comprising tear resistance and crack growth in substituted compounds droppe...

Fusion inhibitors are a class of antiretroviral drugs used to prevent entry of HIV into host cells. Many of the fusion inhibitors being developed, including the drug enfuvirtide, are peptides designed to competitively inhibit the viral fusion protein gp41. With the emergence of drug resistance, there is an increased need for effective and unique alternatives within this class of antivirals. One...

The small natural product rapamycin, when bound to FKBP12, is a potent inhibitor of an evolutionarily conserved Target of Rapamycin Complex 1 (TORC1), which plays a central role in mediating cellular response to nutrient availability. Given the prominent role of TORC1 in cell growth and proliferation, clinical trials have explored the possibility of using rapamycin as an anticancer agent. Unfor...

In this paper, dissimilar resistance spot welding of AISI 1075 eutectoid steel to AISI 201 stainless steel is investigated experimentally. For this purpose, the experiments are designed using response surface methodology and based on four-factor, five-level central composite design. The effects of process parameters such as welding current, welding time, cooling time and electrode force are inv...