OBJECTIVES To present 2 cases of neuroendocrine tumors of the parotid gland and to review the clinical presentation, histopathologic, and immunohistochemical findings and treatment of these rare tumors. STUDY DESIGN Case series. METHODS This study reviews 2 patients who both presented with firm masses in the parotid gland diagnosed as neuroendocrine carcinoma by histopathologic and immunohi...

Sialadenoma papilliferum is a rare benign salivary gland tumor. We present an unusual case of sialadenoma papilliferum of the parotid gland, discuss clinical presentation, diagnostic challenges, and review of the literature. A 65-year-old male smoker presented with a large, exophytic, fungating, painless mass in the tail parotid for 8 years. The tumor developed an exophytic component 2 years be...

Rab3D, a member of the Rab3 subfamily of the Rab/ypt GTPases, is expressed on zymogen granules in the pancreas as well as on secretory vesicles in mast cells and in the parotid gland. To shed light on the function of Rab3D, we have generated Rab3D-deficient mice. These mice are viable and have no obvious phenotypic changes. Secretion of mast cells is normal as revealed by capacitance patch clam...

Primary lymphomas arising from the parotid gland are uncommon and usually account for only 0.6–5% of tumors or tumor-like lesions of the parotid, and therefore are commonly overlooked. Most cases involve the major salivary glands, primarily the parotid (50-93%) and the submandibular glands [1]. The misdiagnosis often leads to unnecessary diagnostic procedures thereby delaying the initiation of ...

Nasopharyngeal carcinoma (NPC) is one of the most common epithelial malignancies in the head and neck region with a marked racial predilection in Southern Chinese, which metastasize to parotid gland, and it is extremely rare. In these populations, it is usually associated with Epstein-Barr virus (EBV). The existence of EBV in tumor cells, aberrant type of antibodies against EBV antigens in pati...

Objective: The purpose of this study was to clarify the diagnostic value of susceptibility weighted imaging (SWI) for distinguishing malignant from benign parotid gland lesions by Magnetic Resonance. Methods: This research prospectively collected the preoperative SWI findings of 41 patients including 12 malignant and 29 benign parotid gland lesions which were confirmed by surgical pathology lat...

BACKGROUND/AIM To investigate the expression of P53, P63, and P73 proteins in malignant parotid gland tumors and adjacent nonneoplastic tissues and the association between the 3 proteins and their clinical characteristics. MATERIALS AND METHODS A total of 40 pairs of paraffin-embedded malignant parotid gland tumors and adjacent nonneoplastic tissues were collected. We detected P53, P63, and P...

The occurrence of a second malignant neoplasm (SMN) in patients who have been submitted to kidney transplantation is increasing and causes concern; parotid carcinoma is rarely reported after transplantation and may be related to long-term chemotherapy.Salivary gland carcinomas displaying exclusively myoepithelial differentiation-myoepithelial carcinomas (EMC) are rare, being less than 1% of all...

BACKGROUND Currently, clinical examination, ultrasound scanning (with or without fine needle aspiration cytology), preoperative CT-scan and MRI are available for the differential diagnosis of parotid gland swelling. A preliminary non-invasive salivary diagnostic tool may be helpful in the clinical decision making process. Altered salivary micro-RNA (miRNA) expression levels have been observed i...

Cystic lymphangioma; Hygroma; Parotid gland; Management Abstract Cystic lymphangioma (CL) of the parotid gland is an uncommon benign congenital tumor and very few cases have been reported in adults. We report and discuss the case of a large CL of the parotid gland in a 66-year-old woman. On computed tomography (CT) the tumor appeared as a large, well defined, unilocular cyst of the parotid regi...