The permeability of junctional complexes to ultrastructural tracers of different molecular weight and the freeze-fracture appearance of junctional structure were investigated in the resting and stimulated rat parotid gland. Tracers were administered retrogradely via the main excretory duct, and allowed to flow by gravity (16 mmHg) into the gland for 15-60 min. Secretion was induced in some anim...

S ialolithiasis is the main cause of unilateral diffuse parotid or submandibular gland swelling. Its incidence has been poorly studied but seems to be much higher than the classic data published by Rauch of 1 case per 300000 people per year. In a recent study, based on hospital admission figures in England, Escudier and McGurk estimated this incidence to be between 1 per 15000 and 1 per 30000. ...

OBJECTIVES To evaluate the outcome of our experience in the treatment of salivary gland disorders in children undergoing sialendoscopy and to assess the evolution of the technique. DESIGN Retrospective medical record review. SETTING Tertiary care university hospital. PATIENTS Thirty-eight children with salivary gland disorders undergoing diagnostic and interventional sialendoscopy between...

Sjögren's syndrome and therapeutic radiation for head and neck cancers result in irreversible changes in the parenchyma of salivary glands, loss of acinar cells, prominence of duct cells, and fibrosis. To clarify mechanisms of salivary gland dysfunction, we identified a signaling pathway involved in the dedifferentiation of primary cultures of parotid acinar cells. We reported previously that t...

OBJECTIVES/HYPOTHESIS Introduce the Chronic Obstructive Sialadenitis Symptoms (COSS) questionnaire to quantify chronic sialadenitis symptoms and assess the impact of sialendoscopic-assisted salivary duct surgery (SASDS). STUDY DESIGN Retrospective outcome symptoms questionnaire study. METHODS The COSS questionnaire assesses the severity of sialadenitis symptoms from 0 to 100. Patients who u...