Parenteral pentavalent antimonials remain the standard therapy for cutaneous leishmaniasis. More effective and patient-compliant topical treatments are an important alternative treatment for the localized self-limiting forms of this disease. Two paromomycin ointments are commercially available but their use is limited by either toxicity or lack of efficacy. Other topical formulations have been ...

Sir: The accomplishment of an efficient method for obtaining the previously unknown 1,3,2"',6"'tetra-N-acetylparomomycin (1) and the subsequent preparation of the pseudotrisaccharide 5-0[3-0(2,6-diami no-2,6-dideoxy-f-L-idopyranosyl)-/3-L-ribo-furanosyl]-2-deoxystreptamine(5), as described in the preceding papery, by nitrous acid deamination, suggested a route for providing a useful intermediat...

We have identified a novel tRNA methyltransferase in Saccharomyces cerevisiae that we designate Trm9. This enzyme, the product of the YML014w gene, catalyzes the esterification of modified uridine nucleotides, resulting in the formation of 5-methylcarbonylmethyluridine in tRNA(Arg3) and 5-methylcarbonylmethyl-2-thiouridine in tRNA(Glu). In intact yeast cells, disruption of the TRM9 gene results...

Susceptibility testing was performed on Dientamoeba fragilis ATCC 30948 in a dixenic culture with Klebsiella pneumoniae and Bacteroides vulgatus. D. fragilis was cocultured with the bacteria in TYGM-9 medium (ATCC medium 1171). The activities of antiparasitic drugs were assessed by counting viable D. fragilis trophozoites with a hemacytometer by trypan blue exclusion. The minimal amebicidal con...

abstract to study the effects of different levels of n, mn and zn on yield and quality of pomegranate fruit a factorial experiment based on complete randomized block design with 18 treatments and three replications was conducted in behshahr city, mazandaran province, in 2009.investigated treatments were include: nitrogen, manganese, zinc. fertilizer source for nitrogen was urea and three rates ...