Objective(s) The aim of this study was to evaluate the effects of dexamethasone on striatal dopaminergic, glutamatergic and gamma amino butyric acid (GABA) ergic neurotransmission in normal and parkinsonian rats. Materials and Methods Dexamethasone (0.15, 0.30, 0.60 and 0.8 mg/kg) was administered to normal or parkinsonian rats (i.p.) followed by the analysis of the striatal neurotransmitter...

This study examined the extent of striatal dopamine (DA) denervation and coincident expression of preproenkephalin (PPE) mRNA in monkeys made parkinsonian by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) administration. Some animals (n = 4) became moderately parkinsonian after receiving large doses of MPTP over short periods of time and were symptomatic for only a short period of time (1-...

Parkinsonian dysarthria is generally known under the name of hypokinetic dysarthria. Dysarthria, according to Darley et al (1969), is characterized by all speech disorders related to disturbances of muscular control of the speech organs, whose origin is a central or peripheral nervous system injury. So we must understand by dysarthria all failures related to either different levels of speech pr...

Accumulating evidence suggests that abnormal neuronal oscillations in the basal ganglia (BG) contribute to the manifestation of parkinsonian symptoms. In this article, we would like to summarize our recent work on the mechanism underlying abnormal oscillations in the parkinsonian state and discuss its significance in pathophysiology of Parkinson's disease. We recorded neuronal activity in the B...

in the present study, the effect of steroidal anti-inflammatory drug betamethasone (0.12, 0.24 mg/kg, i.p. acutely) on striatal glutamate level in parkinsonian rats was studied using the microdialysis technique. our results showed significant differences (p<0.05) in the level of striatal glutamate between treated and non-treated damaged rats.

Dr. Luís Fabiano Marin – Rua Maranhão 192 / 101 01240-000 São Paulo SP Brasil. E-mail: [email protected] Creutzfeldt-Jakob disease (CJD) is a transmissible spongiform encephalopathy or prionic disease characterized by accumulation of abnormal prionic protein (PrP) associated to spongiform degeneration of the brain. Although rare, CJD is the most common prionic disease in humans with an inc...