Cabergoline is a synthetic dopamine agonist used to treat Parkinson disease. The drug occasionally induces pleuropulmonary adverse effects, which manifest as pleural thickening or effusion, interstitial pneumonitis, pulmonary infiltrates, or fibrosis. We report a rare case of pleural effusion and severe pulmonary hypertension in a 79-year-old man with Parkinson disease who had been treated with...

background: noninvasive techniques for the localization of the accessory pathways (aps) might help guide mapping procedures and ablation techniques. we sought to examine the diagnostic accuracy of strain imaging for the localization of the aps in wolff-parkinson-white syndrome. methods: w e prospectively studied 25 patients (mean age = 32 ± 17 years, 58.3% men) with evidence of pre-excitation o...

cognitive deficits such as impairments in attention, memory, information processing and executive functioning can be found in some parkinson's disease (pd) patients. recent studies suggested that pd drivers generally performed poorer than their healthy age-matched controls with regards to their cognitive and motor abilities during the psychometric testing. according to michon’s model of ca...

objective: to investigate the correlation between lower and higher order sensory functions and manual dexterity as well as to identify the sensory measures that could predict manual dexterity in patients with idiopathic parkinson’s disease (pd). materials and methods: in this cross-sectional study, 55 patients with idiopathic pd by mean age of 59.85 ± 11.89 years, and mean hoehn and yahr stage ...

Dementia is a chronic loss of neurocognitive function that is progressive and irreversible. Although rare, dural arteriovenous fistulas (DAVFs) could present with a rapid decline in neurocognitive function with or without Parkinson-like symptoms. DAVFs represent a potentially treatable and reversible cause of dementia. Here, we report the case of an elderly woman diagnosed with a DAVF after pre...

Parkinson disease with diet-induced hyperketonemia: A feasibility study Abstract—Ketones may bypass the defect in complex I activity implicated in Parkinson disease (PD). Five of seven volunteers with PD were able to prepare a “hyperketogenic” diet at home and adhere to it for 28 days. Substituting unsaturated for saturated fats appeared to prevent cholesterol increases in four volunteers. Unif...

BACKGROUND In Japan, selegiline has been approved for combination therapy with levodopa for Parkinson disease (PD). We conducted a trial of selegiline monotherapy for early PD. METHODS In this 12-week controlled phase III trial, a total of 292 subjects were randomized to receive placebo (n = 146) (full analysis set 140) or selegiline (n = 146) (full analysis set 139). The primary outcome meas...