Parathyroid carcinoma is the rarest endocrine cancer with aggressive behaviour. It may be presented as a feature of severe hypercalcemia, musculoskeletal involvement and neck mass. There should high clinical suspicion if there marked very parathyroid hormone levels, palpable mass, recurrent laryngeal nerve palsy due to invasion bone renal symptoms. Thyroid pathology has been seen in 15-70% pati...

Background: Feline hyperthyroidism is the most common endocrine disorder in cats. Cats may not reach the disease control and/or have side effects with medical therapy. Thyroidectomy is a definitive treatment and the only option when radioactive iodine is not available. Extracapsular thyroidectomy with transplantation of the external parathyroid gland is the surgical technique that minimizes the...

Primary hyperparathyroidism (PHPT) is the most common cause of hypercalcemia. Majority of cases are related to single gland adenoma. Parathyroid carcinoma, atypical parathyroid adenoma, parathyroid cysts and parathyromatosis are rare conditions that account for approximately 2% of all patients with PHPT. We report an unusual case of severe hypercalcemia due to cystic atypical parathyroid adenom...

BACKGROUND Numerous studies have reported that age-induced increased parathyroid hormone plasma levels are associated with cognitive decline and dementia. Little is known about the correlation that may exist between neurological processing speed, cognition and bone density in cases of hyperparathyroidism. Thus, we decided to determine if parathyroid hormone levels correlate to processing speed ...

The factors involved in abnormal parathyroid cell secretory function and growth in patients with primary (I degree) and secondary (II degree) hyperparathyroidism are still incompletely understood. We compared the expression of the calcium-sensing receptor (CaR) at the gene message and the protein level in parathyroid tissue obtained from patients with I degree non-uremic or II degree uremic hyp...

Parathyroid scintigraphies have been used to detect pathological parathyroid glands either before as well as after the parathyroid resection surgery in patients with hyperparathyroidism. One of the most utilized techniques to perform the studies is the double-phase images with Tc-99m sestamibi, which has been shown to be very accurate in the localization of enlarged parathyroid glands. Similar ...

Parathyroid cyst is a very rare abnormality. The diagnosis can be made based on ultrasound and the analysis of the aspirated cystic fluid for parathyroid hormone (PTH). We report the case of a nonfunctional parathyroid cyst in a 50-year-old female patient with an anterior neck mass. The patient was complaining of pain in the anterior cervical region, dysphagia, dyspnea and dysphonia started thr...

Starker, L. 2013. New Insights in Genetic and Epigenetic Mechanisms Involved in Parathyroid Tumorigenesis. Acta Universitatis Upsaliensis. Digital Comprehensive Summaries of Uppsala Dissertations from the Faculty of Medicine 927. 36 pp. Uppsala. ISBN 978-91-554-8727-0. Primary hyperparathyroidism (pHPT) is a pathology associated with one or multiple hyperfunctioning parathyroid glands. The dise...

Purpose: Preoperative localization studies for parathyroid adenomas are very essential to perform minimal invasive parathyroidectomy (MIP) with decreased operative time and potential complications. Although most of these studies based on radiological imaging, intraoperative assessment provides the most accurate anatomical description of the location of parathyroid adenomas. In this study, we ai...

Chen, Randolph A., and William G. Goodman.Role of the calcium-sensing receptor in parathyroid gland physiology. Am J Physiol Renal Physiol 286: F1005–F1011, 2004; 10.1152/ajprenal.00013.2004.—The calcium-sensing receptor (CaSR) represents the molecular mechanism by which parathyroid cells detect changes in blood ionized calcium concentration and modulate parathyroid hormone (PTH) secretion to m...