Idiopathic Parkinson's disease (PD) is associated with advanced age, but it is still unclear whether dopaminergic neuronal death results from events initiated during development, adulthood, or represents a cumulative effect across the span of life. This study hypothesized that paraquat (PQ) and maneb (MB) exposure during critical periods of development could permanently change the nigrostriatal...

De todos os herbicidas mundialmente utilizados no meio agrícola, o Paraquat (PQ) tem se mostrado principal responsável por graves intoxicações em humanos. Em estudos realizados nos últimos anos, observa-se um grande número de fatalidades envolvendo a ingestão acidental ou intencional PQ. Diante desse contexto, presente estudo busca identificar, através revisão produções científicas, soluções pa...

The prognosis of paraquat (PQ) poisoning is highly correlated to plasma PQ concentration, which has been identified as the most important index in PQ poisoning. This study investigated the predictive value of coagulation, liver, and kidney indices in prognosticating PQ-poisoning patients, when aligned with plasma PQ concentrations. Coagulation, liver, and kidney indices were first analyzed by v...

The aim of this study is to investigate the molecular mechanisms underlying delayed progressive pulmonary fibrosis, a characteristic of subacute paraquat (PQ) poisoning. Epithelial-mesenchymal transition (EMT) has been proposed as a cause of organ fibrosis, and transforming growth factor-β (TGF-β) is suggested to be a powerful mediator of EMT. We thus examined the possibility that EMT is involv...

In the present work it is demonstrated that Salicylic acid (SA) and Methyl Jasmonate (MeJA) provided protection of photosynthesis (A) against paraquat (Pq) stress and diminished the oxidative damage caused by Pq. Barley seedlings (12d old) were supplied with 500 μM SA, 23 μM MeJA or 10 μM Pq via the transpiration stream and kept in the dark for 24 h. They were then exposed to 100 μmol.m–2.s–1 P...

1-methyl-4-phenylpyridine (MPP+) is the putative toxic metabolite of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and is structurally similar to the herbicide paraquat (PQ++). We have therefore compared the effects of MPP+ and PQ++ on a well characterized experimental model, namely isolated rat hepatocytes. PQ++ generates reactive oxygen species within cells by redox cycling and its toxi...

Alpha-lipoic acid (LA), a metabolic antioxidant, is a natural compound and its biological function has been well studied in various human diseases. The present study was designed to investigate the cytoprotective effect and the molecular mechanisms of LA in paraquat (PQ)-induced oxidative stress injury using BEAS-2B human bronchial epithelial cells. LA co-treatment prevented PQ-induced BEAS-2B ...

This communication is in response to the editorial by G. W. Miller entitled ‘‘Paraquat: The Red Herring of Parkinson’s Disease Research’’ (Toxicol. Sci. 100(1–2), 2007). The author has suggested that research based on the structural similarities between N-N#-dimethyl-4,4#-bipyridinium dichloride (paraquat) and the 1-methyl-4-phenylpyridinium ion (MPPþ) is a red herring that has derailed progres...

The aim of this study was to evaluate the efficacy of unfractionated bone marrow cells (BMCs) in attenuating acute kidney injury (AKI) induced by paraquat (PQ) in a mouse model. PQ (55 mg/kg BW) was intraperitoneally injected into C57BL/6 female mice to induce AKI, including renal function failure, glomerular damage and renal tubule injury. Glomerular podocytes were the first target damaged by ...

BACKGROUND/AIMS Many patients with acute paraquat (PQ) intoxication die even at low PQ concentrations, whereas others with similar concentrations recover. Therefore, it is possible that individual differences in antioxidant capacity are responsible for the variable clinical outcome in patients with acute PQ intoxication. METHODS We investigated whether there was a relationship between the gen...