The body of work on multi-body factorization separates between objects whose motions are independent. In this work we show that in many cases objects moving with different 3D motions will be captured as a single object using these approaches. We analyze what causes these degeneracies between objects and suggest an approach for overcoming some of them. We further show that in the case of multipl...

The presence of degeneracies can considerably worsen the measure of the neutrino oscillation parameters θ13 and δ. We study the physics reach of a specific “CERN” setup, using a standard β-Beam and Super-Beam facility. These facilities have a similar sensitivity in both parameters. Their combination does not provide any dramatic improvement as expected due to their almost identical L/E ratio. W...

BACKGROUND A common characteristic of allergens is that they contain proteases that can activate protease-activated receptor (PAR-2); however the mechanism by which PAR-2 regulates allergic airway inflammation is unclear. METHODS Mice (wild type and PAR-2-deficient) were sensitized using German cockroach (GC) feces (frass), the isolated protease from GC frass, or through adoptive transfer of ...

Sur 2601 admissions, chez 113 enfants at­teints de la maladie de Bouillaud, hospitalises en cinq ans dans deux services de pediatrie de Te­heran (C.H.U. de Pahlavi, C.H.U. de Logman­doleh Adham) 6 cas de manifestations cutanees  (trois cas de nodules, trois cas d'erytheme mar­ginatum) ont ete constates, trois d'entre eux souffrant d'une cardite severe et evolutive.  En Iran !'incidence des si...

Calculations of the number of curves on a Calabi-Yau manifold via an instanton expansion do not always agree with what one would expect naively. It is explained how to account for continuous families of instantons via deformation theory and excess intersection theory. The essential role played by degenerate instantons is also explained.

Extracellular fibrinolysis, controlled by the membrane-bound fibrinolytic system, is involved in cartilage damage and rheumatoid arthritis (RA) synovitis. Estrogen status and metabolism seem to be impaired in RA, and synoviocytes show receptors for estrogens. Our aims in this study were to evaluate in healthy and RA synoviocytes the effects of Raloxifene (RAL), a selective estrogen receptor mod...

Thrombin orchestrates cellular events after injury to the vascular system and extravasation of blood into surrounding tissues. The pathophysiological response to thrombin is mediated by protease-activated receptor-1 (PAR-1), a seven-transmembrane G protein-coupled receptor expressed in the nervous system that is identical to the thrombin receptor in platelets, fibroblasts, and endothelial cells...

INTRODUCTION Tissue factor (TF) activation of the coagulation proteases enhances inflammation in animal models of arthritis and endotoxemia, but the mechanism of this effect is not yet fully understood - in particular, whether this is primarily due to fibrin formation or through activation of protease activated receptors (PARs). METHODS We induced extravascular inflammation by injection of re...

Thrombin and trypsin activate protease-activated receptors (PARs) that modulate vascular tone. In addition to the PARs, thrombin also binds to thrombomodulin via exosite 1, a domain also involved in the interaction of thrombin with PAR-1 but not PAR-2. The purpose of this study was to determine whether thrombomodulin would alter thrombin-induced vasoconstriction, thought to be mediated predomin...