Opium (powdered poppy Capsules) mixed with sugars and other plant products is a popular home made remedy for colic, cough and tonics for infants and children in Baluchistan. Over a period of 7 years (1977.1983) 28 children between the ages of I month to 5 years were admitted in Civil Hospital Quetta due to opium poisoning accounting for 0.16% of all paediatric admissions during the same period....

Opium poppy (Papaver somniferum L.) has two major products: alkaloids in the capsules and the seeds. It is known that opium poppy today contains alkaloid in great quantities. Opiate alkaloids and their synthetic derivatives are widely used in medicines which are produced in hundreds of tons for the medicine industry. The study aimed to screen the capsules of six Turkish opium poppy lines to eva...

Clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated9 (Cas9) endonuclease system is a powerful RNA-guided genome editing tool. CRISPR/Cas9 has been well studied in model plant species for targeted genome editing. However, few studies have been reported on plant species without whole genome sequence information. Currently, no study has been performed to manipulate...

s. Acevska J, Stefkov G, Petkovska R, Kulevanova S, Dimitrovska A. Chemometric approach for development, optimization, and validation of different chromatographic methods for separation of opium alkaloids. Anal Bioanal Chem. 2012 May;403(4):1117-29. Institute of Applied Chemistry and Pharmaceutical Analysis, Faculty of Pharmacy, University Ss. Cyril and Methodius, Skopje, Republic of Macedonia....

An aromatic amino acid decarboxylase DNA fragment was generated from opium poppy (Papaver somniferum L.) genomic DNA by the PCR using primers designed from conserved amino acid sequences of other aromatic amino acid decarboxylase genes. Using this fragment as a probe, a genomic clone was isolated that encodes a new member of the opium poppy tyrosine/3,4-dihydroxyphenylalanine decarboxylase gene...

This article focuses on the uses of opiates in early modern Scotland an effort to trace neglected story how poppy-based substances were used this period across British Isles. It explores their history medical practices, examining sources as varied household recipes, apothecaries’ invoices, and family correspondence surgeons alongside treatises publications seventeenth eighteenth centuries. Cons...

Papaver species are known to produce a large variety of benzylisoquinoline alkaloids, with each species exhibiting a specific alkaloid profile, but only a few genes involved in the biosynthesis or regulation of these complex pathways are known so far. Here we used a genomic approach to discover genes responsible for the determination of a specific alkaloid profile. A stem expressed sequence tag...