OBJECTIVE Three sensitive, selective, and precise spectrophotometric methods based on manipulation of ratio spectra, have been developed and validated for the determination of diclofenac sodium and pantoprazole sodium. MATERIALS AND METHODS The first method is based on ratio spectra peak to peak measurement using the amplitudes at 251 and 318 nm; the second method involves the first derivativ...

Methods/results Recently we evaluated a 48 years old woman for a long lasting suspected multiple drug hypersensitivity. Patient’s medical story was characterized by a proved reflux esophagitis, HP infection, and GERD symptoms that were persistent for over 8 years. During the previous 5 years, different treatments of HP infection based on Amoxicillin, Levofloxacin, and Clarithromycin had induced...

Introduction: Drug induced allergy or hypersensitivity reaction is of great clinical significance in therapeutics. Various factors may contribute like age, genetic composition, disease of the patients and the types of drugs used. Such reactions increases the patient’s suffering and lowers the therapeutic efficacy of any drug. Therefore, it is essential to collect data and investigate important ...

The objective of this study was to investigate the bioequivalence of two formulations of 40 mg pantoprazole sodium enteric-coated tablets: Tripepsa as the test and Pantocid as the reference. The two products were administered as a single oral dose according to a randomized two-phase crossover with a 1-month washout period in 25 healthy Indian volunteers. After drug administration, serial blood ...

stress-related mucosal damage (srmd) is a significant cause of morbidity and mortality in critically ill patients due to the gastrointestinal blood loss. prophylaxis of srmd with proton pump inhibitors or histamine-2 blockers has gained widespread use in intensive care units. both demonstrated to be effective in reducing clinically significant bleedings, while ppis has shown to exert some anti ...

BACKGROUND This study compared the effectiveness and acceptability of all Food and Drug Administration (FDA)-recommended dose proton pump inhibitors (PPIs) in erosive esophagitis (EE): Dexlansoprazole 60 mg, Esomeprazole 40 mg, Esomeprazole 20 mg, Pantoprazole 40 mg, Lansoprazole 30 mg, Rabeprazole 20 mg, Omeprazole 20 mg. METHODS A systematic literature search was performed using PubMed, Emb...

BACKGROUND The appropriate dose of proton pump inhibitors for treatment of patients with upper (GI) bleeding remains controversial. This study compares high-dose versus low-dose intravenous proton pump inhibitor (PPI) infusion for prevention of GI bleeding complications. METHODS A total of 166 patients with bleeding peptic ulcers underwent therapeutic endoscopy using concomitant therapy by argo...