Cannabinoid receptors (CBRs) are involved in neuropsychiatric disturbances including drug addiction. Studies show that single nucleotide polymorphisms (SNPs) of CNR1 and FAAH may contribute to drug addiction and other neuropsychiatric disorders. However, cannabinoid type-2 receptors (CB2Rs) in the CNS and their role in drug addiction and neuropsychiatric disorders have been much less well chara...

Unusual cases of coexistence between Wilson's disease and autoimmune hepatitis have occurred. There are characteristics both diseases in this community patients, laboratory histo pathological findings can be misleading. Wilson disease's clinical appearance differ widely; thus,
 there is not always an easy diagnosis. In addition to being childhood young adult illnesses, also triggered at an...

There is an increasing awareness that autoimmune diseases can present with neuropsychiatric manifestations. We present the case of a 17-year-old female requiring psychiatric hospitalization for obsessive-compulsive disorder and major depressive disorder with mixed affective features, who was subsequently diagnosed with primary Sjogren's syndrome. Treatment with potent immunosuppression resulted...

Anti-LGI1-associated autoimmune encephalitis is a limbic system pathology characterized by persistent seizures, cognitive and neuropsychiatric symptoms treated with immunomodulators depending on the etiology.

BACKGROUND AND OBJECTIVE: Neuropsychiatric conditions represent a large and increasing disease burden in children. A number of drugs are available for the treatment of these conditions, but most drugs have not been adequately tested in children, and off-label drug use remains widespread. We sought to define and quantify recent and ongoing clinical research on the use of neuropsychiatric drugs i...

how to cite this article: shiari r, hassase yegane m, farivar s, javadi parvaneh v, mirjavadi sa. neuropsychiatric symptoms as the first manifestation of juvenile systemic lupus erythematosus: a complicated case with klinefelter’s syndrome. iran j child neurol. 2014 winter; 8(1):62-65. abstract systemic lupus erythematosus (sle) is an autoimmune, multisystem disorder with various manifestations...

Pediatric populations continue to be understudied in clinical drug trials despite the increasing use of pharmacotherapy in children, particularly with psychotropic drugs. Most pertinent to the clinical selection of drug interventions are trials directly comparing drugs against other drugs. The aim was to measure the prevalence of active drug comparators in neuropsychiatric drug trials in childr...