نتایج جستجو برای: pancreatic β cell

تعداد نتایج: 1877157  

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2013
Erica P Cai Xiaohong Wu Stephanie A Schroer Andrew J Elia M Cristina Nostro Eldad Zacksenhaus Minna Woo

Pancreatic endocrine cells expand rapidly during embryogenesis by neogenesis and proliferation, but during adulthood, islet cells have a very slow turnover. Disruption of murine retinoblastoma tumor suppressor protein (Rb) in mature pancreatic β-cells has a limited effect on cell proliferation. Here we show that deletion of Rb during embryogenesis in islet progenitors leads to an increase in th...

Journal: :Islets 2010
Abdelilah Arredouani A Mark Evans Jianjie Ma John Parrington Michael X Zhu Antony Galione

Several recent reports, including one in this journal, have reignited the debate about whether the calcium-mobilizing messenger, nicotinic adenine nucleotide diphosphate (NAADP) plays a central role in the regulation of calcium signalling in pancreatic β-cell. These studies have highlighted a role for NAADP-induced Ca(2+) mobilization not only in mediating the effects of the incretin, GLP-1 and...

2014
Natalia A Tamarina Michael W Roe LH Philipson

Gene manipulation using Cre-loxP recombination has proven to be an important approach for studying the impact of gene expression on pancreatic β-cell biology. We report the generation of a transgenic mouse line that enables a highly specific system for conditional gene manipulation within β-cells and achieve tissue specific and temporally regulated deletion of the Ctnnb1 (β-catenin) gene in pan...

Journal: :American journal of physiology. Endocrinology and metabolism 2011
Adria Giacca Changting Xiao Andrei I Oprescu Andre C Carpentier Gary F Lewis

The phenomenon of lipid-induced pancreatic β-cell dysfunction ("lipotoxicity") has been very well documented in numerous in vitro experimental systems and has become widely accepted. In vivo demonstration of β-cell lipotoxicity, on the other hand, has not been consistently demonstrated, and there remains a lack of consensus regarding the in vivo effects of chronically elevated free fatty acids ...

2017
Joachim Størling Flemming Pociot

Type 1 diabetes (T1D) is a chronic immune-mediated disease resulting from the selective destruction of the insulin-producing pancreatic islet β-cells. Susceptibility to the disease is the result of complex interactions between environmental and genetic risk factors. Genome-wide association studies (GWAS) have identified more than 50 genetic regions that affect the risk of developing T1D. Most o...

2016
Melissa F. Brereton Maria Rohm Kenju Shimomura Christian Holland Sharona Tornovsky-Babeay Daniela Dadon Michaela Iberl Margarita V. Chibalina Sheena Lee Benjamin Glaser Yuval Dor Patrik Rorsman Anne Clark Frances M. Ashcroft

Insulin secretion from pancreatic β-cells is impaired in all forms of diabetes. The resultant hyperglycaemia has deleterious effects on many tissues, including β-cells. Here we show that chronic hyperglycaemia impairs glucose metabolism and alters expression of metabolic genes in pancreatic islets. In a mouse model of human neonatal diabetes, hyperglycaemia results in marked glycogen accumulati...

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