Ginsenoside F1 is a biologically active compound identified potential from Korean Panax ginseng Meyer. In the present study, the potential targets of ginsenoside F1 were investigated by computational target fishing approaches including ADMET prediction, biological activity prediction from chemical structure, molecular docking, and molecular dynamics methods. Results were suggested to express th...

(1) Background: Panax ginseng root is one of the most important herbal products, and the profiling of ginsenosides is critical for the quality control of ginseng roots at different ages in the herbal markets. Furthermore, interest in assessing the contents as well as the localization of biological compounds has been growing. The objective of this study is to carry out the mass spectrometry (MS)...

Panax ginseng has high medicinal and health values. However, the various and complex components of ginseng may interact with each other, thus reducing and even reversing therapeutic effects. In this study, we designed and fabricated a novel "nano-ginseng" with definite ingredients, ginsenoside Rb1/protopanaxadiol nanoparticles (Rb1/PPD NPs), completely based on the protopanaxadiol-type extracts...

Ginseng, the root of Panax species, is a well-known folk medicine. It has been used as traditional herbal medicine in China, Korea and Japan for thousands of years and today is a popular and worldwide used natural medicine. The active ingredients of ginseng are ginsenosides which are also called ginseng saponins. Recently, there is increasing evidence in the literature on the pharmacological an...

Metabolome analysis was carried out to evaluate the effects of light-emitting diode (LED) spectra on the metabolic processes of ginseng (Panax ginseng C. A. Mayer) adventitious roots. In total, 35 hydrophilic and 11 lipophilic metabolites were identified in ginseng roots irradiated with red (630 nm), blue (465 nm) LED light or fluorescent lamp (FL) light, by gas chromatography–time-offlight mas...

Many patients with amyotrophic lateral sclerosis (ALS; motor neuron disease) use natural or traditional therapies of unproven benefit. One such therapy is ginseng root. However, in some other disease models, ginseng has proven efficacious. Ginseng improves learning and memory in rats, and reduces neuronal death following transient cerebral ischemia. These effects of ginseng have been related to...

[This corrects the article DOI: 10.3831/KPI.2015.18.018.].

BACKGROUND Panax ginseng (i.e., ginseng) root is extensively used in traditional oriental medicine. It is a modern pharmaceutical reagent for preventing various human diseases such as cancer. Ginsenosides-the major active components of ginseng-exhibit immunomodulatory effects. However, the mechanism and function underlying such effects are not fully elucidated, especially in human monocytes and...

termed angiogenesis, is a fundamental step in a variety of physiological and pathological conditions including wound healing, embryonic development, chronic inflammation, tumor progression, and metastasis. The process of blood vessel growth can repair tissue damage such as arteriosclerosis, myocardial infarction, and limb ischemia and thus has provided a significant tool for therapeutic neovasc...