BACKGROUND Duhuo Jisheng Wan (DJW) is perhaps the best known and most widely used Chinese herbal recipe for arthralgia, but the clinical study to verify its efficacy is lacking. The purpose of this study was to compare the efficacy of DJW versus diclofenac in symptomatic treatment of osteoarthritis (OA) of the knee. METHODS This study was a randomized, double-blind, double-dummy, controlled t...

BACKGROUND Topically applied nonsteroidal anti-inflammatory drugs (NSAIDs) are used widely for the treatment of pain and inflammation in musculoskeletal disorders. This study compared the analgesic and anti-inflammatory effects of patches of 1% diclofenac-sodium, 3.5% and 0.5% felbinac and 3.75% indomethacin in rats using the carrageenan-induced paw pad edema model and the brewer's yeast-induce...

BACKGROUND Simple and efficient way of pain management after Coronary Artery Bypass Graft (CABG) surgery is an important aspect of patients' care. OBJECTIVES This study aimed to compare the effects of morphine and diclofenac suppositories on postoperative pain management. PATIENTS AND METHODS In this double-blinded clinical trial study, 120 patients aged 30-65 years old, undergone CABG, wer...

BACKGROUND Nonsteroidal anti-inflammatory drugs are the first-line option for treating ankylosing spondylitis (AS) in China. However, no large-scale controlled trials have been conducted in this ethnic population. OBJECTIVE To evaluate the efficacy and safety of 6 weeks' treatment with celecoxib in patients with AS in China. METHODS This Phase 3, double-blind, parallel-group study randomize...

Diclofenac, a non-steroidal anti-inflammatory drug, is prescribed to reduce inflammation and as an analgesic reducing pain in certain conditions. In this study, a sensitive reaction system for quantitative determination of diclofenac was introduced. The method is based on the catalytic effect of diclofenac on the Orange G-bromate reaction system. The change in absorbance was followed spectropho...

BACKGROUND Crocin and safranal are the active substances of saffron and have many biological properties. In the present study, we compared the effects of crocin, safranal and diclofenac on local inflammation and its induced pain in rats. METHODS Local inflammation was induced by intraplantar (ipl) injection of carrageenan (100 μl, 2%). Paw thickness was measured before and after carrageenan i...

Abstract Background: For long time medical scientists have speculated about alleviation of pain so that they have attempted to prescribe a potent analgesic with the least side effects. There are some records in Iranian traditional medicine showing that Elaeagnus angustifolia L. decreases inflammation and pain. Therefore, in this study the analgesic effect of the aqueous extracts of E. angustif...

The efficacy and safety of Nimulid (Nimesulide) and Diclofenac was evaluated in a double blind randomized diclofenac controlled trial in patients suffering from osteoarthritis of the knee joint. Out of 141 patients, 71 (42 mates, 29female) received Nimulid 100 mg. BD and 70 patients (40 male, 30 female) received Diclofenac 75 mg BD. There was no statistically significant difference in the age, ...

Diclofenac sodium is a very common drug used in medical practice for analgesia and is freely available over the counter without any medical prescription. The drug is also the most commonly used or misused by quacks working all over India. Many case reports have been published on upper limb catastrophe of unintentional intra-arterial injection of barbiturates, thiopental sodium, narcotics, and t...