TONS504 (C51H58O5I2) is a chlorin derivative that exhibits photodynamic antimicrobial effect (PAE) on various infectious keratitis pathogens. However, the molecular characteristics of are not well understood. This study aimed to investigate by comparing its singlet oxygen (1O2) quantum yields and PAE with those methylene blue (MB). To measure 1O2 yields, MB were dissolved in phosphate-buffered ...

Leptospira interrogans serovar autumnalis, a causative agent of leptospirosis in Thailand, was isolated from a patient for DNA extraction and amplification of LipL32 gene by polymerase chain reaction (PCR). The 782 bp PCR product was obtained, which was inserted into pAE plasmid with polyhistidine (His6 tag) to construct pAE-LipL32. This recombinant plasmid was transfected into E. coli BL21 (DE...

Early identification of children who experience developmental delays due to prenatal alcohol exposure (PAE) remains a challenge for individuals who do not exhibit facial dysmorphia. It is well-established that children with PAE may still exhibit the cognitive and behavioral difficulties, and individuals without facial dysmorphia make up the majority of individuals affected by PAE. This study em...

Gepotidacin is a first-in-class, novel triazaacenaphthylene antibiotic that inhibits bacterial DNA replication and has in vitro activity against susceptible and drug-resistant pathogens. Reference in vitro methods were used to investigate the MICs and minimum bactericidal concentrations (MBCs) of gepotidacin and comparator agents for Staphylococcus aureus, Streptococcus pneumoniae, and Escheric...

Methods Pattern analysis of a chorological dataset, consisting of the occurrences of 3041 vascular plant species in each of the 50 km 9 50 km UTM cells of a grid covering Iberia and the Balearic Islands, was based on cluster analysis (unweighted pair-group method using arithmetic averages; UPGMA) and parsimony analysis of endemicity (PAE). The Jaccard similarity index was used in the UPGMA, and...

antimicrobial activity of carbapenems, the postantibiotic effect (PAE) is a prominent feature. Carbapenems have been shown to produce PAEsnot only against Grampositive bacteria but also against Gram-negative bacteria by several investigators1 ~ 5). The aim of the present study was to simultaneously compare the PAE of newer carbapenems (such as meropenemand biapenem) with that of imipenemagainst...

Short Abstract—A simplified inverse class F power amplifier (PA) with a voltage second harmonic peaking and third harmonic short operating at 2.14GHz for WCDMA base station applications has been developed. The load network is based on transmission line harmonic traps and provides high impedance at the second and low impedance at the third harmonic to the PA. The PA uses a packaged Silicon LDMOS...