We tested the hypothesis that interruption of motor traffic running down the spinal cord to respiratory muscle motoneurons suppresses the ventilatory response to increased chemical drive. We compared the hypoxic (HVR) and hypercapnic (HCVR) ventilatory responses, based on the rebreathing technique, before and during inspiratory flow-resistive loading in 17 quadriplegic patients with low cervica...

Peripheral chemoreceptors (carotid bodies) are the main sensing organs for hypoxaemia. During carotid surgery, the carotic body in the bifurcation of the common carotid artery is often involved and damaged or destroyed. Animals lose their ability to adapt to high altitude after experimental denervation of the carotid bodies. The objective of our study was to evaluate the ability of human patien...

BACKGROUND AND AIM In patients with cystic fibrosis (CF) the architecture of the developing lungs and the ventilation of lung units are progressively affected, influencing intrapulmonary gas mixing and gas exchange. We examined the long-term course of blood gas measurements in relation to characteristics of lung function and the influence of different CFTR genotype upon this process. METHODS ...

Background: Acute methanol poisoning is one of the most important chemical poisoning due to drinking of illegal and handmade alcoholic beverages in Iran. The aim of this study was to evaluate clinical and biochemical parameters as prognostic factor in acute methanol poisoning. Methods: A retrospective study was performed on acute methanol poisoning cases admitted to the Loghman Hakim Hospital P...

Background: We studied in a group of patients admitted for acute severe asthma (ASA) arterial blood gases at admission and it relationship with airway obstruction. We also compared arterial gases of a subgroup of patients unable to perform spirometry because their poor clinical status with those able to complete the test. Methods. Data from arterial gases and spirometry were obtained from two p...

Background The best ventilation mode that suits with LMAs is still unclear. In this study, we investigated the ventilatory performance of Baska masks in patients who underwent elective laparoscopic cholecystectomy under general anaesthesia and pneumoperitoneum either volume-controlled (VCV) or pressure-controlled (PCV) mode.Methods Fifty-Six ASA I – II, cholecystectomy, were randomly classified...

INTRODUCTION End tidal CO2 (ETCO2) has been established as a standard for confirmation of an airway, but its role is expanding. In certain settings ETCO2 closely approximates the partial pressure of arterial CO2 (PaCO2) and has been described as a tool to optimize a patient's ventilatory status. ETCO2 monitors are increasingly being used by EMS personnel to guide ventilation in the prehospital ...