نتایج جستجو برای: p38 map kinase inhibitors

تعداد نتایج: 577103  

Journal: :International journal of oncology 2009
Binod Kumar Jane Sinclair Lakshmipathi Khandrika Sweaty Koul Shandra Wilson Hari K Koul

Transitional cell carcinoma (TCC) is the most common form of bladder cancer. In bladder cancer, which in terms of its origins and genetics, is a representative of invasive tumors, the differing clinical course and the limited value of established prognostic markers compelled many researchers to look for new molecular parameters in predicting the prognosis and treatment of patients with bladder ...

Journal: :American journal of physiology. Heart and circulatory physiology 2005
Tomohiko Sumida Hajime Otani Shiori Kyoi Takayuki Okada Hiroyoshi Fujiwara Yoshihisa Nakao Masakuni Kido Hiroji Imamura

p38 MAP kinase activation is known to be deleterious not only to mitochondria but also to contractile function. Therefore, p38 MAP kinase inhibition therapy represents a promising approach in preventing reperfusion injury in the heart. However, reversal of p38 MAP kinase-mediated contractile dysfunction may disrupt the fragile sarcolemma of ischemic-reperfused myocytes. We, therefore, hypothesi...

Journal: :American journal of physiology. Lung cellular and molecular physiology 2006
Raja-Elie E Abdulnour Xinqi Peng Jay H Finigan Eugenia J Han Emile J Hasan Konstantin G Birukov Sekhar P Reddy James E Watkins Usamah S Kayyali Joe G N Garcia Rubin M Tuder Paul M Hassoun

Xanthine oxidoreductase (XOR) plays a prominent role in acute lung injury because of its ability to generate reactive oxygen species. We investigated the role of XOR in ventilator-induced lung injury (VILI). Male C57BL/6J mice were assigned to spontaneous ventilation (sham) or mechanical ventilation (MV) with low (7 ml/kg) and high tidal volume (20 ml/kg) for 2 h after which lung XOR activity a...

Journal: :Frontiers in bioscience : a journal and virtual library 2008
Maria Perander Stephen M Keyse Ole-Morten Seternes

MAP kinase-activated protein kinase 5 (MK5) was originally described as a protein kinase activated downstream of the p38 MAP kinase and is also named p38-regulated/activated protein kinase (PRAK). However, while MK5 is most similar in sequence to the two p38 regulated MAPKAP kinases MK2 and MK3, recent data has shown that in contrast to these enzymes MK5 is not activated in response to either c...

Journal: :Journal of cell science 2001
Y Sawada K Nakamura K Doi K Takeda K Tobiume M Saitoh K Morita I Komuro K De Vos M Sheetz H Ichijo

Mechanical force or mechanical stress modulates intracellular signal pathways, including the mitogen-activated protein kinase (MAP kinase) cascades. In our system, cell stretching activated and cell contraction inactivated all three MAP kinase pathways (MKK1/2-extracellular signal-regulated kinase (ERK), MKK4 (SEK1)-cJun N-terminal kinase (JNK) and MKK3/6-p38 pathways). However, little is known...

Journal: :The Biochemical journal 2005
Víctor Javier Sánchez-Arévalo Lobo Clara Isabel Aceves Luquero Luis Alvarez-Vallina Alex J Tipping Juan Guinea Viniegra Javier Hernández Losa Carlos Parada Cobo Eva María Galán Moya Jorge Gayoso Cruz Junia V Melo Santiago Ramón y Cajal Ricardo Sánchez-Prieto

The chimaeric protein Bcr/Abl, the hallmark of chronic myeloid leukaemia, has been connected with several signalling pathways, such as those involving protein kinase B/Akt, JNK (c-Jun N-terminal kinase) or ERKs (extracellular-signal-regulated kinases) 1 and 2. However, no data about the p38 MAPK (mitogen-activated protein kinase) have been reported. Here, we present evidence showing that Bcr/Ab...

Journal: :Pharmacology Biochemistry and Behavior 2012
Gabriela F. Pavao-de-Souza Ana C. Zarpelon Giovana C. Tedeschi Sandra S. Mizokami Joice S. Sanson Thiago M. Cunha Sérgio H. Ferreira Fernando Q. Cunha Rubia Casagrande Waldiceu A. Verri

The acetic acid and phenyl-p-benzoquinone are easy and fast screening models to access the activity of novel candidates as analgesic drugs and their mechanisms. These models induce a characteristic and quantifiable overt pain-like behavior described as writhing response or abdominal contortions. The knowledge of the mechanisms involved in the chosen model is a crucial step forward demonstrating...

Journal: :The Biochemical journal 2004
Konstantina Nika Huong Hyunh Scott Williams Surojit Paul Nunzio Bottini Kjetil Taskén Paul J Lombroso Tomas Mustelin

The HePTP (haematopoietic protein tyrosine phosphatase) is a negative regulator of the ERK2 (extracellular signal-regulated protein kinase 2) and p38 MAP kinases (mitogen-activated protein kinases) in T-cells. This inhibitory function requires a physical association of HePTP through an N-terminal KIM (kinase-interaction motif) with ERK and p38. We previously reported that PKA (cAMP-dependent pr...

Journal: :Investigative ophthalmology & visual science 2001
Z M Bian V M Elner A Yoshida S L Kunkel S G Elner

PURPOSE To determine the signal mediators involved in glycated human serum albumin (GHSA) stimulation of interleukin (IL)-8 and monocyte chemotactic protein (MCP)-1 secretion in human retinal pigment epithelium (hRPE) cells. METHODS hRPE cells were stimulated by GHSA in the presence or absence of a series of kinase inhibitors. The induced IL-8 and MCP-1 mRNA and proteins were determined by re...

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