4-Nitroquinoline 1-oxide (4NQO) damages bacterial genomes but not phage genomes. A reduction product of 4NQO, 4-hydroxyaminoquinoline 1-oxide (4HAQO), damages both the bacterial and phage genomes. These results imply that Salmonella typhimurium is able to convert 4NQO to 4HAQO and that 4HAQO reacts with the genomes. When phage P22 is treated with 4HAQO and assayed on S. typhimurium strains lyso...

Angiotensin II (ANG II) infusion increases renal superoxide (O(2)(-)) and enhances renal vasoconstriction via macula densa (MD) regulation of tubuloglomerular feedback, but the mechanism is unclear. We targeted the p22(phox) subunit of nicotinamide adenine dinucleotide phosphate (NADPH) oxidase (NOX) with small-interfering RNA (siRNA) to reduce NADPH oxidase activity and blood pressure response...

BACKGROUND AND PURPOSE Superoxide has been implicated in the pathogenesis of ischemic stroke and atherosclerosis. NADPH oxidase, a major source of superoxide generation in neutrophils and the vascular system, plays a critical role in ischemic injury and atherogenesis. Recently, an association between the C242T polymorphism of p22 PHOX, an essential component of NADPH oxidase, and coronary arter...

Penicillin-induced spheroplasts of Salmonella typhimurium strain LT2 lysogenic for bacteriophage P22, appear to lose immunity to superinfection by homologous phage.

Translation is shown to be downregulated sharply between genes V and VII of IKe, a filamentous bacteriophage classed with the Ff group (phages f1, M13, and fd) but having only 55% DNA sequence identity to it. Genes V and VII encode the following proteins which are used in very different amounts: pV, used to coat the large number of viral DNA molecules prior to assembly, and pVII, used to serve ...