Objective. To determine whether a combination of borage seed oil rich in gamma linolenic acid (GLA) and fish oil rich in eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) is superior to either oil alone for treatment of rheumatoid arthritis (RA). Methods. Patients were randomized into a double-blind, 18-month trial. Mixed effects models compared trends over time in disease activity mea...

Objective: Alzheimer's disease (AD) is the most common form of dementia, can be created in experimental models by using toxins. Possible therapeutic effects secondary metabolites Rosmarinic (RA) and Oleanolic acids (OA) obtained from Salvia species (sage) were investigated histopathological immunohistochemical tecniques Alzheimer's-like dementia model induced scopolamine.
 Study Design: Ma...

Soon after [1 1-3H]retinoic acid (RA) (1.1 x 108 d.p.m.) was administered orally to rats either as a large dose (115 ,ug = 0.38 /tmol/rat) or mixed with unlabelled RA as a huge dose (22 mg = 73.33 ,umol/rat), retinoyl ,-glucuronide (RAG) was identified and characterized as a significant metabolite in the serum and small intestine. Of the administered dose, 70 % remained unchanged as retinoic ac...

Program Number: 1300 Presentation Time: 8:30 AM–8:45 AM Retinoic Acid Improves Keratocyte Phenotype in a 3D Model of the Corneal Stroma Ricardo M. Gouveia, Fadhilah Z. Abidin, Che J. Connon. Institute of Genetic Medicine, Newcastle University, Newcastle-upon-Tyne, United Kingdom. Purpose: Retinoic Acid (RA) is a metabolite of vitamin A fundamental for the correct function and development of the...

Retinoic acid (RA) displays pronounced anticarcinogenic activities in several types of cancer. Whereas the mechanisms that underlie this activity remain incompletely understood, tumor suppression by RA is believed to emanate primarily from its ability to regulate transcription of multiple target genes. Here, we investigated molecular events through which RA inhibits the growth of MCF-7 mammary ...

objective: embryonic stem cells (escs) are pluripotent cells capable of extensive proliferation while maintaining their potential to differentiate into any cell type. the therapeutic potential of these cells are promising, but in many cases limited by our inability to promote their differentiation. in this study we examined the effect of inducer factors in direct differentiation of mouse escs i...

BACKGROUND & AIMS All-trans Retinoic acid (RA) regulates hepatic lipid and bile acid homeostasis. Similar to bile acid (BA), RA accelerates partial hepatectomy (PHx)-induced liver regeneration. Because there is a bidirectional regulatory relationship between gut microbiota and BA synthesis, we examined the effect of RA in altering the gut microbial population and BA composition and established ...

Retinoic acid (RA) exhibits anti-inflammatory, anti-tumor, and immuno-modulatory actions, and affects angiogenesis and thrombosis. Arachidonic acid (AA) metabolites are involved in all these processes. We explored the effect of RA on AA metabolism in human umbilical vein endothelial cells (HUVECs). 13-cis-RA increased the release of prostaglandin I(2) (PGI(2)), both spontaneous and thrombin-ind...