INTRODUCTION Vilazodone is a potent serotonin (5-HT) reuptake inhibitor and 5-HT₁A receptor partial agonist approved by the US Food and Drug Administration for the treatment of major depressive disorder (MDD) in adults. This study evaluated the efficacy and tolerability of vilazodone in the treatment of MDD. METHOD This 8-week, randomized (1:1), double-blind, placebo-controlled, parallel-grou...

Objectives. To compare reconstructive techniques, operative times, duration of hospitalization, and need for subsequent flap revisions between reconstructive approaches to lateral skull base defects. Study Design. Case series with chart review. Setting. Tertiary academic referral center. Subjects. Patients (n = 31) undergoing reconstruction of composite lateral skull base defects from 2002 to 2...

A quantitative assessment of the mannose resistant, adhesive property of Escherichia coli from patients with ulcerative colitis and from controls was made using a buccal epithelial cell adhesion assay, which also permitted assessment of adhesion to cells from other host sources. E coli from patients with ulcerative colitis adhered to buccal epithelial cells to a greater extent than those obtain...

Over 30 genomic regions show linkage to asthma traits. Six asthma genes have been cloned, but the putative loci in many linked regions have not been identified. To search for asthma susceptibility loci, we performed genomewide univariate linkage analyses of seven asthma traits, using 202 Australian families ascertained through a twin proband. House-dust mite sensitivity (Dpter) exceeded the emp...

Dr. Fredrickson is from the Department of 'Preventive Medicine, University of Kansas School of Medicine, Wichita, Kansas. Dr. Davis is lrom the Departments of Pediatrics and Internal Medicine and Dr. Bocchini is lrom the Department of Pediatrics, Louisiana State Universihj Health Sciences Center-Shreveport, Shreveport, Louisiana. Address reprint requests to Terry C. Davis, PhD, Department of In...