The tubuloglomerular feedback (TGF) mechanism is a negative feedback loop that senses changes in luminal NaCl delivery at the macula densa (MD) in the juxtaglomerular apparatus and adjusts the vascular tone of the afferent arteriole accordingly.1 This mechanism contribute importantly to the kidney’s ability to regulate renal microcirculation, fluid homeostasis, and, consequently, blood pressure...

ACQUIRED WEAKNESS SYNDROMES in critically ill patients have been shown to be a major cause of mortality and long-term morbidity (4, 7). A key component of these syndromes is the development of respiratory muscle weakness, which leads to prolonged duration of mechanical ventilation, difficulty weaning patients from the ventilator, and recurrence of respiratory failure after extubation. Clinical ...

The tubuloglomerular feedback (TGF) mechanism is a negative feedback loop that senses changes in luminal NaCl delivery at the macula densa (MD) in the juxtaglomerular apparatus and adjusts the vascular tone of the afferent arteriole accordingly.1 This mechanism contribute importantly to the kidney’s ability to regulate renal microcirculation, fluid homeostasis, and, consequently, blood pressure...