Accumulating evidence indicates that aldosterone plays a critical role in the mediation of oxidative stress and vascular damage. NADPH oxidase has been recognized as a major source of oxidative stress in vasculature. However, the relation between NADPH oxidase in aldosterone-mediated oxidative stress in endothelial cells remains to be ascertained. The present study aimed to investigate the rel...

neopterin, apyrazinopyrimidine compound, is produced by macrophages after induction by interferon gamma (ifn-y) and serves as a marker of cellular immune system activation followed by oxidative stress. the aim of this study was to determine urinary neopterin to creatinine ratio (uncr) as a surrogate marker of cell-mediated immune activation in multiple sclerosis (ms). three weekly early morning...

M. Bansal and N. Kaushal, Oxidative Stress Mechanisms and their Modulation, DOI 10.1007/978-81-322-2032-9_2, © Springer India 2014 Oxidative stress has been well implicated in the pathogenesis of various human diseases. Presently mechanistic considerations of the oxidative stress pathogenesis in most vital organ systems, e.g., nervous system, cardiovascular system, male/ female reproductive sys...

background: glucocorticoids have several benefits in large animal medicine but apart from their benefits, there are several disadvantages attributed to the use of these drugs. among the disadvantages, disturbance in protein metabolism is one of the side effects of glucocorticoids which has been investigated in human and laboratory animals. objectives: there are no information regarding the effe...

toxic effects of monensin, a polyether antibiotic mainly used as a coccidiostat, have been described in a wide range of animals. the present study was performed to investigate the toxic effects of monensin in goats. seven adult goats were administered sodium monensin, 13.5 mg kg-1, daily for five consecutive days via gastric gavage. monensin toxicity was evaluated by clinical signs, serum bioch...

grape seed proanthocyanidin (gsp) bears a very powerful antioxidant effects. studies demonstrated that proanthocyanidins protect against free radicals mediated cardiovascular and renal disorders. the present study was designed to assess the effect of gsp on the heart of diabetic rats. forty rats were divided into four groups of 10 animals each: group i: control, group ii: control group were giv...

camel milk has an importance in the treatment of diabetes. it has been shown that the patients who drink camel milk daily, their need to insulin decrease. therefore, this study aimed to investigate the effect of camel milk in comparison with insulin treatment in experimentally-induced diabetes. this study was carried out on forty male new zealand rabbits, divided into four groups with ten rabbi...

objective: it has been shown that deferasirox can reduce blood and tissues lead content in animal models. in this study the effect of deferasirox alone or combined with glycine as an antioxidant was evaluated in chronic cadmium toxicosis in rat. methods: male wistar albino rats were exposed to 200 ppm cadmium in the drinking water for 3 weeks and treated thereafter with deferasirox (140 mg/kg),...

conclusions in the literature, it was observed that short-term msg exposure does not cause significant histological changes in the kidneys, liver, or brain cortex. these findings should be re-evaluated in additional long-term studies. background monosodium glutamate (msg) is a widely-used flavor enhancer and stabilizer in ready-made or packaged foods. the excessive use of msg has been shown to ...

conclusions it may be concluded that combination of losartan with higher dose of va decreases ischemic markers and lipid peroxidation and augments endogenous antioxidant and hence, protects myocardium against i/r-induced oxidative stress injuries. results there was a more significant decrease in the levels of ldh, cpk, ck-mb, and mda as well as increase in the levels of sod, cat and gpx in grou...