O xidation processes are essential in normal cell metabolism. Free radicals, i.e. reactive oxygen and nitrogen compounds, are formed continuously. They participate in metabolic and cell signalling pathways, in spite of their potentially deleterious effects. A system of endogenous anti-oxidative compounds and systems operates to control strictly the concentrations and actions of free radicals. D...

BACKGROUND Cadmium is a potent neurotoxic heavy metal, which induces oxidative stress and membrane disturbances in brain. Melatonin is an effective antioxidant and free radical scavenger against oxidative stress. The present study was designed to investigate the neuroprotective efficacy of melatonin in protecting the Cd induced changes in the activity of acetylcholinesterase (AChE), levels of l...

metals can cause oxidative stress by increasing the formation of reactive oxygen species (ros), which make antioxidants incapable of defiance against growing amounts of free radicals. metal toxicity is related to their oxidative state and reactivity with other compounds. however, several reports about metals have been published in the recent years. mitochondria, as a site of cellular oxygen con...

standardization of induction of oxidative stress with fenton mixture (fm) in isolated perfused rat kidney and the antioxidant effect of terminalia arjuna bark in the isolated oxidatively stressed rat kidney has been evaluated. six groups each containing eight isolated perfused rat kidneys were used for the present study and the oxidative stress was induced by perfusing the isolated kidneys with...

BACKGROUND & OBJECTIVES The human system possesses antioxidants that act harmoniously to neutralize the harmful oxidants. This study was aimed to evaluate the serum total antioxidant capacity (TAC) as a single parameter in Eales' disease (ED) and in an acute inflammatory condition such as uveitis and in cataract which is chronic, compared to healthy controls. METHODS The TAC assay was done sp...

Beta thalassemia major is an inherited disease resulting from reduction or total lack of beta globin chains. Patients with this disease need repeated blood transfusion for survival. This may cause oxidative stress and tissue injury due to iron overload, altered antioxidant enzymes, and other essential trace element levels. The aim of this review is to scrutinize the relationship between oxidati...

Mushrooms are a group of fleshy macroscopic fungi. They have been valued throughout the world as both edible and medicine. They are highly nutritious with good amount of quality proteins, vitamins and minerals. An edible mushroom, Calocybe indica was selected to validate its nutritional and medicinal properties. Since tissue damage in hyperglycemia has been related to oxidative stress, we evalu...

We investigated oxidative stress in human postmortem frontal cortexfrom individuals characterized as mild cognitive impairment (n= 8), mild/moderate Alzheimer disease (n = 4), and late-stage Alzheimer disease (n = 9). Samples from subjects with no cognitive impairment (n = 10) that were age- and postmortem interval-matched with these cases were used as controls. The short postmortem intervalbra...

INTRODUCTION Chronic myeloid leukaemia (CML) is a myeloproliferative disorder of the haematopoietic cell. Free radicals can be important causative agents of a number of human diseases, including cancer and leukaemia. Thus, antioxidants, which control the oxidative stress state, represent a major line of defense for regulating the overall true state of health. The relationship between non-enzyma...

The production of free radicals has a role in the regulation of biological function, cellular damage, and the pathogenesis of central nervous system conditions. Epilepsy is a highly prevalent serious brain disorder, and oxidative stress is regarded as a possible mechanism involved in epileptogenesis. The aim of this study is to evaluate the status of some antioxidants in epileptic patients and ...