نتایج جستجو برای: oxazolidinone antibiotic
تعداد نتایج: 82349 فیلتر نتایج به سال:
This thesis documents the design and synthesis of chiral amino alcohol monomers 161, 162,167, chiral oxazolidine monomer 168 and chiral oxazolidinone monomers 203 and 204. The synthetic strategy relies on the key Suzuki coupling of aryl triflates derived from tyrosine with p-vinylphenylboronic acid where the resultant vinyl monomers are further modified to provide the desired functionality. / M...
Derivatives of the two unusual 8-hydroxy amino acids in echinocandin D (1) have been synthesized by employing asymmetric glycine enolate aldol methodology. The N-Boc,O-benzyl derivative of (2S,3R)-3-hydroxyhomotyrosine (Hht) (2) and the methyl ester of (2.9,3S,4.9)-3-hydroxy-4-methylproline (Hmp) (3) have been synthesized in four steps each from (isothiocyanoacety1)oxazolidinone 4 and (bromoace...
Staphylococcal resistance to linezolid (LZD) is mediated through ribosomal mutations (23S rRNA or ribosomal proteins L3 and L4) or through methylation of 23S rRNA by the horizontally transferred Cfr methyltransferase. To investigate the structural basis for oxazolidinone activity against LZD-resistant (LZD(r)) strains, we compared structurally diverse, clinically relevant oxazolidinones, includ...
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