نتایج جستجو برای: oxa 48

تعداد نتایج: 144813  

Journal: :The Journal of biological chemistry 2013
David E Ehmann Haris Jahic Philip L Ross Rong-Fang Gu Jun Hu Thomas F Durand-Réville Sushmita Lahiri Jason Thresher Stephania Livchak Ning Gao Tiffany Palmer Grant K Walkup Stewart L Fisher

Avibactam is a non-β-lactam β-lactamase inhibitor with a spectrum of activity that includes β-lactamase enzymes of classes A, C, and selected D examples. In this work acylation and deacylation rates were measured against the clinically important enzymes CTX-M-15, KPC-2, Enterobacter cloacae AmpC, Pseudomonas aeruginosa AmpC, OXA-10, and OXA-48. The efficiency of acylation (k2/Ki) varied across ...

Journal: :Antimicrobial agents and chemotherapy 2014
Laurent Dortet Laurent Poirel Patrice Nordmann

Recently, Tijet et al. evaluated the Carba NP test (1), which we developed in order to identify carbapenemase producers. Our first study included 316 carbapenemaseand non-carbapenemase-producing Enterobacteriaceae and Pseudomonas aeruginosa isolates (2, 3). Tijet et al. confirmed that this biochemical test has an excellent specificity of 100%, together with an excellent positive predictive valu...

Journal: :Indian Journal of Biochemistry & Biophysics 2023

Due to an increase in serious infections and a lack of efficient therapies, Klebsiella pneumoniae has recently gained more recognition. The production carbapenemases is one the most common strategies by which K. acquire resistance carbapenems considered last resort antibiotics. Previously collected isolates from different clinical settings on basis their genetic profile, mainly absence presence...

Journal: :Enfermedades infecciosas y microbiologia clinica 2014
J M Rodríguez Martínez P Díaz-de Alba Lopez-Cerero G Ruiz-Carrascoso R Gomez-Gil A Pascual

A study is presented on the presence of quinolone resistance qnrB1 genes in clinical isolates belonging to the largest series of infections caused by OXA-48-producing Klebsiella pneumoniae in a single-centre outbreak in Spain. Evidence is also provided, according to in vitro results, that there is a possibility of co-transfer of plasmid harbouring blaOXA-48 with an other plasmid harbouring qnrB...

Journal: :Clinical Chemistry 2023

Abstract Background The identification, treatment, and control of carbapenem-resistant Enterobacteriaceae (CRE) infections are a major challenge for health care institutions diagnostic laboratories worldwide. A novel Carbapenemase-producing Bacteria Test Kit (Lateral Flow Assay) from Dynamiker Biotechnology (Tianjin) Co., Ltd. is qualitative test that was easy to operate can be widely accepted ...

Journal: :Antimicrobial stewardship & healthcare epidemiology 2023

Objectives: The increase in carbapenemase-producing organism (CPO) transmission among hospitalized patients is a growing concern. Studies investigating the of CPO to epidemiologically linked contacts are scarce. We conducted an interim subgroup analysis ongoing multicenter household Singapore (CaPES-C) study identify acquisition rate patients. Methods: This prospective cohort was between Januar...

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