Microphthalmia in sheep is an autosomal recessive inherited congenital anomaly found within the Texel breed. It is characterized by extremely small or absent eyes and affected lambs are absolutely blind. For the first time, we use a genome-wide ovine SNP array for positional cloning of a Mendelian trait in sheep. Genotyping 23 cases and 23 controls using Illumina's OvineSNP50 BeadChip allowed u...

Passive immunotherapy may have particular benefits for the treatment of severe influenza infection in at-risk populations, however little is known of the impact of passive immunotherapy on the formation of memory responses to the virus. Ideally, passive immunotherapy should attenuate the severity of infection while still allowing the formation of adaptive responses to confer protection from fut...

Prion diseases are associated with the conversion of the normal cellular prion protein, PrP(c), to the abnormal, disease-associated form, PrP(Sc). This conversion can be mimicked in vitro by using a cell-free conversion assay. It has recently been shown that this assay can be modified to use bacterial recombinant PrP as substrate and mimic the in vivo transmission characteristics of rodent scra...

Purinton, Scott C., Howard Newman, Maria I. Castro, and Charles E. Wood. Ontogeny of estrogen sulfatase activity in ovine fetal hypothalamus, hippocampus, and brain stem. Am. J. Physiol. 276 (Regulatory Integrative Comp. Physiol. 45): R1647–R1652, 1999.—Ovine parturition is initiated by increases in fetal hypothalamus-pituitary-adrenal (HPA) axis activity, which in turn increase placental estro...

1. Şevik M. Genomic characterization of pestiviruses isolated from bovine, ovine and Caprine foetuses in Turkey: A potentially new genotype pestivirus I species. Transbound Emerg Dis. 2020;68(2):417–426. https://doi.org/10.1111/tbed.1.... CrossRef Google Scholar

A lentivirus has been isolated from a Finnish ewe with ovine progressive pneumonia in a closed upstate New York flock. We demonstrated that the virus, designated ovine lentivirus strain CU1 (OLV-CU1), is biologically, biochemically and molecularly related to, but distinct from, previously described sheep and goat lentiviruses. Nine of 32 ewes (from the affected flock) with precipitating antibod...

This research has performed for detection of Aspergillus species (A. fumigatus, A. flavus, A. niger and A. terreus) in aborted bovine, ovine, caprine and camel foetuses by real-time PCR in Iran. After modification of real-time PCR on abomasal contents, from the total number of 970 samples, 141 (14.53%) gave positive results for Aspergillus species. Of them, 62 (17.71%), 33 (14.04%), 27 (12.05%)...

An extract of ovine and bovine pineal glands (labeled Precipitate II) has previously been shown to possess lipolytic activity on rabbit adipose tissue. This extract also causes darkening of the frog’s skin in vivo and in vitro. Both lipolytic and melanotropic activities are abolished by trypsin and chymotrypsin. Fractionation of ovine pineal Precipitate II by the sequence, chromatography on die...

A woman in the first trimester of pregnancy presented with pneumonia and hilar lymphadenopathy after exposure to lambing ewes. She subsequently aborted. Infection with Chlamydia psittaci of ovine origin was confirmed. Pregnant women are susceptible to this infection, which may cause life threatening disease. The patient also had features of sarcoidosis, and the two conditions ran a similar time...