UNLABELLED α(2)-adrenoceptors (AR) lower central sympathetic output and peripheral catecholamine release, thereby protecting against sympathetic hyperactivity and hypertension. Norepinephrine re-uptake-transporter effectively (NET) removes norepinephrine from the synapse. Overflow to plasma will therefore not reflect release. Here we tested if inhibition of re-uptake allowed presynaptic α(2)AR ...

We introduce a general non-Gaussian, self-similar, stochastic process called the fractional Lévy motion (fLm). We formally expand the family of traditional fractal network traffic models, by including the fLm process. The main findings are the probability density function of the fLm process, several scaling results related to a singleserver infinite buffer queue fed by fLm traffic, e.g., scalin...

Background A thorough knowledge of the metabolism and its compartmentation in mammalian cells is desirable to enable rational design and optimization of producing cell lines and production processes for biopharmaceuticals. In this study we focused on acquiring a detailed understanding of metabolite channelling and the metabolic flux distribution during overflow metabolism in the human cell line...

Protocols for synchronizing data streams should be highly adaptive with regard to both changing network conditions as well as to individual user needs. The stream synchronization protocol we are going to describe in this paper supports any type of distribution of the stream group to be synchronized. It incorporates buffer level control mechanisms allowing an immediate reaction on overflow or un...

It was hypothesized that stuttering may be related to impaired sensory gating, leading to overflow of superfluous disturbing auditory feedback and breakdown of the speech sequence. This hypothesis was tested using the acoustic startle prepulse inhibition (PPI) paradigm. A group of 22 adults with developmental stuttering were compared with controls regarding the degree of PPI. No significant dif...

Context: The success of Stack Overflow and other community-based question-and-answer (Q&A) sites depends mainly on the will of their members to answer others’ questions. In fact, when formulating requests on Q&A sites, we are not simply seeking for information. Instead, we are also asking for other people’s help and feedback. Understanding the dynamics of the participation in Q&A communities is...

We performed experiments to determine the effects of acetylstrophanthidin (ACS) and ouabain on the adrenergic neuroeffector junction in dog saphenous veins. In quiescent strips incubated with 3H-norepinephrine (3H-NE), the drugs caused contraction and a progressive increase in overflow of 3H-NE and O-methylated metabolites; 3,4-dihydroxyphenylglycol (DOPEG) decreased. Tissue uptake of 3H-NE was...