T lymphoma invasion and metastasis 1 (Tiam1), a guanine nucleotide exchange factor, was originally identified as an invasionand metastasis-inducing gene in T lymphoma cells. High expression levels of the human Tiam1 gene have been found in numerous human malignancies, suggesting a potential role as a modifier of tumor initiation and progression. However, little is known about the status of Tiam...

Background: The ovarian neoplasms are the cause of highest mortality in female genital tract. Histomorphological study is the gold standard to assess the treatment modalities and prognosis of various tumors. Aim: This study is done to determine the age incidence, prevalence and morphological variants of ovarian neoplasms Materials and methods: This is retrospective and prospective study done fr...

PURPOSE We used conventional cytogenetics, molecular cytogenetics, and molecular genetic analyses to study the pattern of allelic loss on chromosome 6q in a cohort of borderline epithelial ovarian tumors. EXPERIMENTAL DESIGN Fifteen tumor samples were collected from patients undergoing surgery for ovarian tumors. The tumors of borderline malignancy, classified according to the standard criter...

OBJECTIVE The aim of this study was to estimate the 5-year survival of ovarian cancer in Iran between 2000 and 2004, according to age and histology. METHODS Cancer registry of Iran, 2000-2004, was used covering nearly 80% of all ovarian cancers and 100% of all pathologically diagnosed ovarian cancers. RESULTS Of 1,246 new ovarian cancer cases, 451 were available for further follow-up, which...

The ovary is itself a hormone secreting organ, and it has been shown that some ovarian tumors also secrete hormones. Granulosa cell tumors and theca cell tumors are hormone secreting tumors. There have been many reports on the histogeneses, character, and nomenclatures of these tumors. In 1944, Biskind et al. reported the development of granulosa cell tumors and luteoma by intrasplenic ovarian ...

Ovarian microcystic stromal tumors (MCSTs) and ovarian primary solid pseudopapillairy neoplasms (SPNs) are rare ovarian tumors, and recently classified as distinctive variant in the stromal category and miscellaneous tumors respectically in 2009 and 2010. Ever since, there were less then 10 MCSTs and ovarian primary SPNs reported in English literatures. Both of them had something in common, inc...

BACKGROUND Studies of alternative mRNA splicing (AS) in health and disease have yet to yield the complete picture of protein diversity and its role in physiology and pathology. Some forms of cancer appear to be associated to certain alternative mRNA splice variants, but their role in the cancer development and outcome is unclear. METHODS We examined AS profiles by means of whole genome exon e...

AIM OF THE STUDY Establishing a characteristic pattern for the stromal ovarian tumors. MATERIAL AND METHODS We realized the clinical-statistics analyze of 27 stromal tumors (lot B) from a total of 498 patients with ovarian tumors (lot A), diagnosed and treated between 1999 - 2008 in Elena Doamna Hospital of Obstetrics and Gynecology, lasi. We used the clinical files of these patients, operato...

Background Ovarian cancer still remains the deadliest cancer of the female reproductive tract. Unfortunately, most cases are diagnosed in the late stages of the disease. The most useful tumor marker in the detection of ovarian cancer is cancer antigen (CA) 125. The greatest problem of CA 125 determination is its lack of specificity. Aim To evaluate the clinicopathological features of ovarian tu...

Previous studies indicated that a new member of the human kallikrein (KLK) gene family, KLK4, was expressed in prostate, breast, and endometrial carcinoma cell lines and may have potential as a tumor marker. The aim of this study was to examine the expression of KLK4 in the normal ovary and ovarian tumors of different histology, stage, and differentiation and to determine its association with o...