Diminished ovarian function occurs early and is a primary cause for age-related decline in female fertility; however, its underlying mechanism remains unclear. This study investigated the roles that genome and epigenome structure play in age-related changes in gene expression and ovarian function, using human ovarian granulosa cells as an experimental system. DNA methylomes were compared betwee...

Estrogen receptor (ER) β has growth inhibitory and chemo drug potentiating effect on ovarian cancer cells. We studied the dependence of ERβ function on the presence of KDM6B and SIRT1 in human ovarian cancer cells in vitro. Activation of ERβ with the subtype-selective agonist KB9520 resulted in significant inhibition of human ovarian cancer cell growth. KB9520-activated ERβ had an additive effe...

Background: Understanding ovarian folliculogenesis is critical to the study of fertility and in the development of fertility techniques as well as contraception. Mares and women share striking similarities in ovarian folliculogenesis, and in insulin resistance and obesity syndromes. The effects of insulin resistance and obesity on follicular development and the surrounding endocrinology and gen...

BACKGROUND Questions remain as to whether surgical excision of ovarian endometriomas might cause damage to ovarian function. To test the hypothesis that ovarian surgery for endometrioma compromises ovarian function and accelerates ovarian failure. METHODS In a tertiary university Clinic, longitudinal prospective cohort study. Patients who underwent laparoscopy for endometriosis between March ...

BACKGROUND With infertility populations in the developed world rapidly aging, treatment of diminished ovarian reserve (DOR) assumes increasing clinical importance. Dehydroepiandrosterone (DHEA) has been reported to improve pregnancy chances with DOR, and is now utilized by approximately one third of all IVF centers world-wide. Increasing DHEA utilization and publication of a first prospectively...

Ovulation in the absence of the ovarian surface epithelium in the primate. Biol Reprod 2010;82:599–605. Wright JW, Jurevic L, Stouffer RL. Dynamics of the primate ovarian surface epithelium during the ovulatory menstrual cycle. Hum Reprod 2011a; 26:1408–1421. Wright JW, Pejovic T, Jurevic L, Bishop CV, Hobbs T, Stouffer RL. Ovarian surface epitheliectomy in the non-human primate: continued cycl...

the objective of this study was to examine the correlation between both midfollicular fsh/lh ratio and number(s) of follicles with ovarian hyperstimulation syndrome (ohss) in patients with polycystic ovarian syndrome (pcos). this was carried out in ivf unit at mirza kouchak khan hospital. to induce ovulation, pcos patients were stimulated with gonadotropines. fifty four pcos patients with norma...

Early menopause and infertility often occur in female cancer patients after chemotherapy (CTx). For these patients, oocyte/embryo cryopreservation or ovarian tissue cryopreservation is the current modality for fertility preservation. However, the above methods are limited in the long-term protection of ovarian function, especially for fertility preservation (very few females with cancer have ac...

With the evolution of the treatment of malignant neoplasms, the survival rates of patients undergoing chemo- or radiotherapy are increasing. The continuous development of techniques of assisted human reproduction has led to important strategies in an attempt to maintain reproductive function in patients subjected to treatment of neoplastic diseases, among them cryopreservation of embryos, gamet...