Recent advances in the development of animal models for Lyme borreliosis have provided means of identifying potential targets for the design of a subunit vaccine to prevent this disease. The C3H/HeN mouse model was used to study several Borrelia burgdorferi antigens from a single isolate for their ability to elicit borreliacidal and protective antibodies. The ospA, ospB, ospC, ospD, and 83-kDa ...

neisseria meningitidis is a major causative agent of bacterial septicemia and meningitis in humans. currently, there are no vaccines to prevent disease caused by strains of n.meningitidis serogroup b. the class 1 outer membrane protein (omp) has been named pora which is a cation selective transmembrane protein of 45 kda that forms trimeric pore in the meningococcal outer membrane. pora from ser...

Surface expression of the group 1 K30 capsular polysaccharide of Escherichia coli strain E69 (O9a:K30) requires Wza(K30), a member of the outer membrane auxiliary (OMA) protein family. A mutation in wza(K30) severely restricts the formation of the K30 capsular structure on the cell surface, but does not interfere with the biosynthesis or polymerization of the K30 repeat unit. Here we show that ...

The threat posed to human health by arthropod-borne bacteria is most vividly demonstrated by the devastating epidemics caused by the plague. The diversity of pathogenic bacteria spread by arthropods is probably underestimated. Recently recognized infectious diseases such as Lyme disease and ehrlichiosis are caused by bacteria transmitted by arthropods. Bacteria which alternate between arthropod...