OBJECTIVE To analyze immunocompetent cells as well as 2 factors involved in inflammation and also thought to be involved in bone remodeling-interleukin 6 (IL-6) and inducible nitric oxide synthase in the human middle ear, including the tympanic membrane. DESIGN Biopsy specimens were obtained from the human middle ear and tympanic membrane during surgery. Using an immunohistochemical technique...

OBJECTIVE: To compare the air deflation pressure of the eustachian tubes in patients with tympanic membrane perforations due to various forms of otitis media and those with myringotomy or blast injury perforations. METHODS: The study group consisted of 321 patients (407 ears) aged 4 months to 91 years with tympanic membrane perforations due to otitis media (318 ears), blast injury (27), and myr...

BACKGROUND The prevalence of otitis media in Greenlandic children is one of the highest in the world. International studies have shown that otitis-prone children may benefit from tubulation of the tympanic membrane. However, it is unknown whether these results can be applied to Greenlandic children and trials on the effects of ventilation tubes in high-risk populations have, to our knowledge, n...

1. Preston D, Therasse D, Zeckel ML. Cefaclor and cefuroxime axetil in the treatment of otitis media—an alternative view [letter]. J Infect Dis 1998;178:1547–8 2. Dagan R, Abramson O, Leibovitz E, et al. Bacteriologic response to oral cephalosporins: are established susceptibility breakpoints appropriate in the case of acute otitis media? J Infect Dis 1997;176:1253–9. 3. Dagan R, Leibovitz E, G...

A 12-month study of the incidence of acute otitis media in children under three years of age in an urban practice of 10 000 patients showed that acute otitis media accounted for one in 10 of all episodes of illness presented. In contrast to findings in Scandinavia and the USA the incidence of acute otitis media in the first year of life (11.5%) was lower than in the second year (28.6%). The stu...

CONTEXT Adenoidectomy and adenotonsillectomy are commonly performed in US children to reduce the occurrence of persistent or recurrent otitis media, but evidence supporting the efficacy of the operations is limited. OBJECTIVES To test the efficacy of adenoidectomy and adenotonsillectomy in children with persistent or recurrent otitis media who had not previously undergone tube placement and t...

CONTEXT Prescribing practices for otitis media are not consistent with current evidence-based recommendations. OBJECTIVE To determine whether point-of-care evidence delivery regarding the use and duration of antibiotics for otitis media decreases the duration of therapy from 10 days and decreases the frequency of prescriptions written. DESIGN Randomized, controlled trial. SETTING Primary ...

BACKGROUND Acute myringitis is an inflammation of the tympanic membrane that occurs alone or in association with external otitis or otitis media. The two clinical entities, based on physical examination, are bullous myringitis and hemorrhagic myringitis. OBJECTIVES To investigate the association of concomitant middle ear disease with acute myringitis and to analyze the bacteriologic findings ...