نتایج جستجو برای: osteogenic
تعداد نتایج: 9151 فیلتر نتایج به سال:
BACKGROUND/AIMS Insulin-like growth factor binding proteins (IGFBP) play important roles in bone metabolism. IGFBP4 is involved in senescent-associated phenomena in mesenchymal stem cells (MSCs). The goal of the present study was to determine whether age-related IGFBP4 overexpression is associated with the impaired osteogenic differentiation potential of aged bone marrow derived MSCs. METHODS...
Estrogen plays an important role in the maintenance of bone formation, and deficiency in the production of estrogen is directly linked to postmenopausal osteoporosis. To date, the underlying mechanisms of estrogen-mediated osteogenic differentiation are not well understood. In this study, a pluripotent mesenchymal precursor cell line C2C12 was used to induce osteogenic differentiation and subje...
In recent decades, stem cell therapy has been introduced as a novel therapeutic approach for patients suffering from bone disorders. Recently, menstrual blood has been identified as an easily accessible and recycled stem cell source. However, the osteogenic differentiation capacity of menstrual blood-derived stem cells (MenSCs) compared with other adult stem cells remained unsolved. The aim of ...
The aim of this study was to evaluate the effect of porous biphasic calcium phosphate (BCP) scaffolds on the proliferation and osteoblastic differentiation of human periodontal ligament cells (hPDLCs) in the presence and absence of osteogenic inducer (L-ascorbic acid, dexamethasone and β-glycerophosphate). The cell growth within the scaffolds in the absence of osteogenic inducers was studied by...
Ferutinin is a daucane sesquiterpene with a high estrogenic activity in vitro and in vivo (Appendino et al., 2002; Zavatti et al., 2009). Recently, we demonstrated that ferutinin is able to enhance proliferation and osteogenic differentiation of human amniotic fluid stem cells (AFSCs) (Zavatti et al., 2013). Morover, the oral administration in rats of this phytoestrogen improved the bone regene...
*Ho, CY; *Chen, WM; *Chen, TH; +*Lee, OK +*Taipei Veterans General Hospital, Taiwan [email protected] Introduction: Bone morphogenetic protein-4 (BMP-4) possesses osteoinductive activities and is known to induce osteogenic differentiation in mesenchymal stem cells (MSCs). It has been reported that BMP signaling is associated with the PTEN/PI3 Kinase/AKT signaling pathway which subsequently al...
This study investigates the proliferative and osteogenic role of marrow stromal/osteoprogenitor cells in the development of the cortical bone deficit in ovariectomized (OVX) female rats. In vitro, clonal growth of marrow stromal cells from OVX rats was significantly impaired (vs. sham-operated controls). Yet in vivo, cells from sham-operated and OVX rats had equal osteogenic potential in severa...
Reference 1. Linero I, Chaparro O (2014) Paracrine Effect of Mesenchymal Stem Cells Derived from Human Adipose Tissue in Bone Regeneration. PLoS ONE 9(9): e107001. doi:10.1371/journal.pone.0107001 PMID: 25198551 Fig 3. Ad-MSC characterization. A. Osteogenic differentiation of Ad-MSC. Osteogenic differentiation was evidenced by the detection of calcium deposits with Alizarin Red staining. a. Con...
Osteosarcoma (OS) is associated with poor prognosis due to its high incidence of metastasis and chemoresistance. It often arises in areas of rapid bone growth in long bones during the adolescent growth spurt. Although certain genetic conditions and alterations increase the risk of developing OS, the molecular pathogenesis is poorly understood. Recently, defects in differentiation have been link...
The ability of mesenchymal stem cells (MSCs) to differentiate into osteogenic lineages requires management for their future use in treating bone destruction and osteoporosis. Hepcidin is closely associated with bone metabolism, however, it remains to be elucidated whether hepcidin affects osteogenic differentiation in MSCs. The present study demonstrated that hepcidin enhanced osteoblastic diff...
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