Abstract Objectives The present study was performed to determine if minocycline HCl could influence the behavior of deproteinized bovine bone mineral (DBBM) and bioactive glass (BG) particles when used as filler material for new generation in a guided augmentation model. Materials Methods Two occlusive titanium caps were placed on rat calvaria. One filled with BG particles, second DBBM both pre...

Strontium (Sr) substituted calcium phosphate (CaP) coatings have stimulated a lot of interest as Sr is known to provide osteoconductive properties. Most the work date with respect has focused on creation crystalline Sr-substituted hydroxyapatite (HA), opposed amorphous coatings. The reported here utilises radio frequency magnetron sputtering deposit both CaP and Sr-containing their characterisa...

Materials and Methods: The graft materials were assessed for bone healing efficacy in the athymic rat posterolateral fusion (PLF) model. This model has been extensively characterized to ensure that there are not instances of spontaneous fusion, and instead that the fusion results from the osteogenic, osteoconductive and/or osteoinductive nature of the graft materials. The transverse processes o...

Recent advances in biomaterial technology have made alloplastic bone substitutes more predictable when used with the proper clinical methodology in carefully selected patients. In this animal study, early bone formation using a novel resorbable bioactive glass in the repair of surgically created bony defects in the rat mandible was investigated. Biopsies taken from the implanted sites after 1, ...

Up to now, there are enormous efforts to develop such coatings that can enhance the biocompatibility properties of metallic implant materials (Ti, Ti6Al4V, CoCrMo, stainless steel) and even provide antimicrobial effect. The most interesting candidates for these coatings are calcium phosphate (CaP) or specifically hydroxyapatite (HAp) phases due to their biocompatibility, osteoconductive propert...

The aim of this work is the microscopic study of the dynamics of the healing of the defect of compact bone tissue after the implantation into its cavity of osteoplastic material «easy-graft CRYSTAL». The experiment was conducted on 24 Wistar rats. In the middle third of the femoral shaft of rats there was reproduced perforated defect in the diameter of 2.5 mm to the medullary canal, which was f...

Bioactive-glass (B-G) is a material known for its favorable biological response when in contact with surrounding fibro-osseous tissues, due not only to an osteoconductive property, but also to an osteostimulatory capacity, and superior biocompatibility for use in human body. The objectives of this paper are to review recent studies on B-G in periodontal and implant therapy, describing its basic...

INTRODUCTION: Composites of purified collagen and calcium phosphate salts have been widely used to produce osteoconductive scaffolds for fracture healing and spinal fusion. The effects of different calcium phosphate additives in a collagen scaffold was previously investigated in a rat model of ectopic bone formation induced by a mixture of bovine bone derived growth factors. It was found that o...

Conflicting clinical outcomes have been reported recently with the use of an osteochondral scaffold plugs for cartilage repair in the knee. In this study, twenty patients were consecutively treated for their cartilage lesions with the synthetic plug technique. These patients were prospectively clinically evaluated with a mean follow-up of 34.15 months. Magnetic resonance imaging (MRI) was used ...

The purpose of the work was to study the features of reparative osteogenesis for filling the defect of tubular bone under implantation of mesh titanium nickelide constructs. Tibial fenestrated defect was modeled experimentally in 30 Wistar pubertal rats, followed by implant intramedullary insertion. The techniques of radiography, scanning electron microscopy and X-ray electron probe microanalys...