INTRODUCTION Knee osteoarthritis (OA) can be classified as primary (nontraumatic) or secondary (post-traumatic). Variations in radiological features exist between these knee OA classifications [1]. Differences in gait mechanics have not been investigated and this information may provide knowledge about the role of gait in OA initiation and progression. The purpose was to compare gait kinematics...

Articular calcification correlates with osteoarthritis (OA) severity but its exact role in the disease process is unclear. In examining OA meniscal cell function, Sun and colleagues have shown recently that meniscal cells from end-stage OA subjects can generate calcium crystals and that genes involved in calcification are upregulated in OA meniscal cells. Also, this in vitro calcium deposition ...

Osteoarthritis (OA) affects 250 million people worldwide. Currently, no targets for disease-modifying osteoarthritis drugs exist. Matrix metalloproteinase-13 (MMP-13) would make it an ideal target; however, its broad biological effects restrict its application as a target enzyme of inhibitory drugs in the treatment of OA. The expression and activation of discoidin domain receptor 2 (DDR2) is in...

Purpose: Physical activity (PA) may improve work ability and health in individuals with hip and/or knee osteoarthritis (OA). The use of wearable trackers (WATs) has been shown to increase PA other outcomes but little is known concerning their effect on ability. objectives this study were examine the self-monitoring a WAT ability, productivity among working age OA.

OBJECTIVES To assess the influence of occupational exposures on risk of site-specific radiographic osteoarthritis (OA) of the knee, hand, foot, and cervical spine. METHODS Using a cross-sectional design, data collected from men and women aged 40 years and older participating in the Clearwater Osteoarthritis Study were analyzed (n = 3436). Subjects' occupational exposures were queried using th...

Quadriceps dysfunction, specifically weakness and central activation failure (CAF), has been implicated in the development and progression of knee osteoarthritis (OA), though few data are available to confirm its presence in early OA. The purpose of this study was to determine the presence and magnitude of quadriceps dysfunction in those with and without early knee OA. Thirty-five female volunt...

BACKGROUND Inflammation plays a crucial role in the development and progression of osteoarthritis (OA). Interleukin-15 (IL-15) is a well-known proinflammatory cytokine. OBJECTIVE We aimed at evaluating the relationship between serum IL-15 levels and the severity of pain as well as radiographic progression in patients with knee OA. METHODS Two hundred and twenty-six OA patients and 106 contr...

BACKGROUND This study aimed to investigate the bone morphogenetic protein-2 (BMP-2) levels in serum and synovial fluid (SF) of patients with primary knee osteoarthritis (OA) and to exam its correlation with radiographic and symptomatic severity of the disease. MATERIAL/METHODS A total of 37 knee OA patients and 20 healthy controls were enrolled in this study. Knee OA radiographic grading was ...

In the present study, the levels of synovial fluid biomarkers of patients with knee osteoarthritis (OA) and those with meniscus injury (MI) were compared to associate the levels of synovial fluid biomarkers with the degree of OA and MI. Synovial fluid samples were obtained from 51 cases with OA and 40 patients with MI. Severity of OA and MI were evaluated using the Kellgren-Lawrence (K-L) class...