Monkeypox virus (MPXV) is considered the most significant human public health threat in the genus Orthopoxvirus since the eradication of variola virus (the causative agent of smallpox). MPXV is a zoonotic agent endemic to forested areas of Central and Western Africa. In 2003, MPXV caused an outbreak in the United States due to the importation of infected African rodents, and subsequent sequenti...

As part of a program to identify new compounds that have activity against orthopoxviruses, a number of 4'-thionucleosides were synthesized and evaluated for their efficacies against vaccinia and cowpox viruses. Seven compounds that were active at about 1 microM against both viruses in human cells but that did not have significant toxicity were identified. The 5-iodo analog, 1-(2-deoxy-4-thio-be...

A zoonotic orthopoxvirus known as monkeypox inadvertently produces a smallpox-like illness in humans but with far fewer fatalities. This infection is indigenous to most parts of the African continent, outbreaks throughout Western World linked exotic animal trade and travel abroad, making it therapeutically significant. Vaccinating against smallpox had historically resulted coincidental immuniza...

Monkeypox (MKP) is a zoonosis caused by DNA virus belonging to the Orthopoxvirus genus in Poxviridae family and was isolated for first time Denmark, 1958. In 1970, case humans described Democratic Republic of Congo and, since then, it has spread with inter-human dissemination July 2022, WHO declared state health emergency. Its clinical presentation similar that smallpox, skin eruptions evolve a...

Introduction: Monkeypox is a viral illness caused by an enveloped double-stranded DNA virus that belongs to the genus orthopoxvirus in Poxviridae family. Until now, available data on perinatal outcomes pregnant people with monkeypox infection acquired pregnancy are still limited. Case Report: We report case of 33-year-old woman confirmed polymerase chain reaction (PCR) skin lesions. She had spo...

Camelpox virus (CMLV) gene 176R encodes a protein with sequence similarity to murine schlafen (m-slfn) proteins. In vivo, short and long members of the m-slfn family inhibited T-cell development, whereas in vitro, only short m-slfns caused arrest of fibroblast growth. CMLV 176 protein (v-slfn) is most closely related to short m-slfns; however, when expressed stably in mammalian cells, v-slfn di...

Orthopoxvirus species like cowpox, vaccinia and monkeypox virus cause zoonotic infections in humans worldwide. Infections often occur in rural areas lacking proper diagnostic infrastructure as exemplified by monkeypox, which is endemic in Western and Central Africa. While PCR detection requires demanding equipment and is restricted to genome detection, the evidence of virus particles can comple...