In vitro, e-polylysine (EPL) strongly inhibited the hydrolysis of trioleoylglycerol emulsified with phosphatidylcholine (PC) and taurocholate by either pancreatic lipase or carboxylester lipase. The EPL concentration required for 50% inhibition of pancreatic lipase, 0.12 mM, was eight times lower than the concentration of orlistat required for the same effect. The 50% inhibition concentration b...

Question There is a large population of overweight and obese children in my clinic. What medications for treatment of obesity are effective and can be used in children? Answer Orlistat is the only medication indicated by the US Food and Drug Administration for the treatment of obesity in adolescents. It is approved by the Food and Drug Administration for use in adolescents aged 12 years and old...

Obesity is a medical condition in which excess body fat has accumulated to such an extent that it may have an adverse effect on health, leading to reduced life expectancy (Haslam and James, 2005). The lifestyle treatments directed at improving diet and physical activity are considered as first line treatment for obesity; however, if these fail, antiobesity medication is recommended. In the past...

The synthesis of β-thiolactone and β-lactam analogs of tetrahydrolipstatin is described from a common late-stage β-lactone derivative. These analogs, and a cis-disubstituted β-lactone analog of tetrahydrolipstatin, were screened for activity against porcine pancreatic lipase and for inhibition of cell growth of a panel of four human cancer lines.

New medications like the gastric inhibitory polypeptide (GIP) and glucagon-like peptide-1 receptor agonist (GLP-1 RA) have been making headlines as more effective weight loss medications. However, in light of recent manufacturing delays, cost side effects, older should still be considered. A 58-year-old female with history metabolic syndrome depression presented to endocrinology clinic discuss ...

The term “obesity” implies an excess of adipose tissue (fat) and excess adiposity is a health risk. In most cases it develops in the absence of any underlying disease process. It is always due to greater calorie intake than is expended; the mystery lies in the cause of the energy imbalance. Recently there has been a tremendous surge of interest in understanding the mechanisms controlling energy...

OBJECTIVE To systematically review and describe currently available approaches to supporting maintenance of weight loss in obese adults and to assess the evidence for the effectiveness of these interventions. DESIGN Systematic review with meta-analysis. DATA SOURCES Medline, PsycINFO, Embase, and the Cochrane Central Register of Controlled Trials. STUDY SELECTION Studies were identified t...

AIMS Obesity causes a high disease burden in Australia and across the world. We aimed to analyse the cost-effectiveness of weight reduction with pharmacotherapy in Australia, and to assess its potential to reduce the disease burden due to excess body weight. METHODS We constructed a multi-state life-table based Markov model in Excel in which body weight influences the incidence of stroke, isc...